2'-O-Propargyl-adenosine
(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-prop-2-ynoxyoxolan-3-ol
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemical Name
- (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-prop-2-ynoxyoxolan-3-ol
- MF
- C13H15N5O4
- MW
- 305.29
- Purity
- 98%
2'-O-Propargyl-adenosine is a modified adenosine nucleoside bearing a 2'-O-propargyl sugar substituent. Key identifiers include CAS 151390-97-5, molecular formula C13H15N5O4, molecular weight 305.29, and PubChem CID 22885207.
The 2'-O-propargyl group provides a terminal alkyne handle, placing this nucleoside in click-compatible oligonucleotide research contexts. It should be presented as a modified nucleoside/reference compound, not as a protected CE phosphoramidite monomer.
Synonyms
2'-O-propargyladenosine; 2'-O-propargyl adenosine
Identity and specifications
| Catalog No. | CH70066 |
| CAS No. | 151390-97-5 |
| Molecular Formula | C13H15N5O4 |
| Molecular Weight | 305.29 |
| Exact Mass | 305.11240398 |
| PubChem CID | 22885207 |
| InChIKey | ROHGEAZREAFNTO-QYVSTXNMSA-N |
| Structural Note | Adenosine nucleoside with a 2'-O-propargyl sugar modification |
| Purity | 98% |
Storage conditions
-20 C for powder; -80 C in solvent
Technical attributes
- Material class
- 2'-O-propargyl nucleoside
- Nucleobase
- Adenine
- Sugar modification
- 2'-O-propargyl
- Conjugation handle
- Terminal alkyne
- Grade
- N (Normal)
- Packaging
- 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; Custom packaging on request
- Physical form
- Solid
- Stability
- 3 years at -20 C for powder; 1 year at -80 C in solvent
Application context
- Click-compatible oligonucleotide chemistry: 2'-O-propargyl nucleoside chemistry is reported in enzymatic oligonucleotide preparation and DNA click-modification contexts.
- Alkyne-handle nucleoside: the 2'-O-propargyl substituent provides a terminal alkyne handle for structure-aware click-chemistry research workflows.
- Modified-nucleoside reference: use as a structure and identifier reference for 2'-O-propargyl adenosine chemistry.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 22885207
PubChem · CID 22885207
Frequently Asked Questions
What is 2'-O-Propargyl-adenosine?
It is a modified adenosine nucleoside bearing a 2'-O-propargyl sugar substituent. PubChem confirms CAS 151390-97-5 under stereospecific CID 22885207.
What does the propargyl group add?
The 2'-O-propargyl group provides a terminal alkyne handle, which places this type of nucleoside in click-compatible oligonucleotide chemistry contexts.
Is CH70066 a phosphoramidite monomer?
No. CH70066 is documented as the modified nucleoside 2'-O-Propargyl-adenosine. A protected CE phosphoramidite would require separate structural evidence and identifiers.
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