5'-O-DMT-2'-O-TBDMS-N1-methyl-pseudouridine
5-[(2S,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-1-methylpyrimidine-2,4-dione
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemical Name
- 5-[(2S,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-1-methylpyrimidine-2,4-dione
- MF
- C37H46N2O8Si
- MW
- 674.9
- Purity
- >=98.0% (HPLC)
5'-O-DMT-2'-O-TBDMS-N1-methyl-pseudouridine is catalog CH70331. PubChem resolves CAS 875302-41-3 to CID 67259612, with molecular formula C37H46N2O8Si, molecular weight 674.9, exact mass 674.30234296, and InChIKey LAUAFECHUGXCAW-NXVJRICRSA-N.
This entry describes a protected N1-methylpseudouridine nucleoside bearing 5'-O-DMT and 2'-O-TBDMS groups. It is distinct from the corresponding CE phosphoramidite derivative and is positioned here for modified-nucleoside synthesis research and structure matching.
Synonyms
5'-O-(4,4'-Dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-N-methylpseudouridine; 5'-O-DMT-2'-O-TBDMS-N1-methyl-pseudouridine (source name)
Identity and specifications
| Catalog No. | CH70331 |
| Product Name | 5'-O-DMT-2'-O-TBDMS-N1-methyl-pseudouridine |
| CAS No. | 875302-41-3 |
| Molecular Formula | C37H46N2O8Si |
| Molecular Weight | 674.9 |
| Exact Mass | 674.30234296 |
| PubChem CID | 67259612 |
| InChIKey | LAUAFECHUGXCAW-NXVJRICRSA-N |
| Synonyms | 5'-O-DMT-2'-O-TBDMS-N1-methylpseudouridine; protected N1-methylpseudouridine nucleoside; CAS 875302-41-3 |
| Purity | >=98.0% (HPLC) |
Storage conditions
-15 to -25 C
Technical attributes
- Material class
- Protected N1-methylpseudouridine
- Nucleoside identity
- N1-Methylpseudouridine
- 2'-O protection
- TBDMS
- 5'-O protection
- DMT
- Packaging
- Custom packaging on request
Application context
- Protected nucleoside intermediate: CAS 875302-41-3 and PubChem CID 67259612 support a 5'-O-DMT, 2'-O-TBDMS, N1-methylpseudouridine protected nucleoside identity.
- DMT/TBDMS-protected derivative work: the DMT and TBDMS protecting groups make this entry relevant to research workflows that require protected N1-methylpseudouridine derivatives.
- Derivative distinction: formula C37H46N2O8Si and InChIKey LAUAFECHUGXCAW-NXVJRICRSA-N help distinguish CH70331 from CE phosphoramidite derivatives.
Additional material information
Uses
Use this catalog entry for research-oriented identity matching, protected pseudouridine derivative work, and catalog searches involving DMT/TBDMS-protected N1-methylpseudouridine.
Characteristics
5'-O-DMT-2'-O-TBDMS-N1-methyl-pseudouridine is represented here as a protected modified nucleoside. Use the CAS number, PubChem CID, formula, exact mass, and InChIKey when aligning this entry with product specifications.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 67259612
PubChem · CID 67259612
Frequently Asked Questions
What is 5'-O-DMT-2'-O-TBDMS-N1-methyl-pseudouridine?
It is catalog CH70331. PubChem resolves CAS 875302-41-3 to CID 67259612, with formula C37H46N2O8Si and molecular weight 674.9.
Is CH70331 the same as the CE phosphoramidite derivative?
No. CH70331 is the protected nucleoside identity for CAS 875302-41-3. The CE phosphoramidite derivative has a different CAS, formula, and structure.
Similar Products
Need Help with Material Selection?
CHEMOS can review product fit, target structure, route questions, analytical expectations, and project-specific supply needs.