5'-O-DMT-2'-O-TBDMS-pseudouridine
5-[(2S,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-1H-pyrimidine-2,4-dione
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemical Name
- 5-[(2S,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-1H-pyrimidine-2,4-dione
- MF
- C36H44N2O8Si
- MW
- 660.8
- Purity
- >=98.0% (HPLC)
5'-O-DMT-2'-O-TBDMS-pseudouridine is catalog CH70335. PubChem resolves CAS 144429-56-1 to CID 168438028, with molecular formula C36H44N2O8Si, molecular weight 660.8, exact mass 660.28669290, and InChIKey ZWMZNCKRGUDPLZ-FEFKUCBWSA-N.
This entry describes a protected pseudouridine nucleoside bearing 5'-O-DMT and 2'-O-TBDMS groups. It is distinct from CE phosphoramidite derivatives and is positioned here for modified-nucleoside synthesis research and structure matching.
Synonyms
5'-O-DMT-2'-O-TBDMS-Pseudouridine; 5'-O-DMT-2'-O-TBDMS-pseudouridine (source name)
Identity and specifications
| Catalog No. | CH70335 |
| Product Name | 5'-O-DMT-2'-O-TBDMS-pseudouridine |
| CAS No. | 144429-56-1 |
| Molecular Formula | C36H44N2O8Si |
| Molecular Weight | 660.8 |
| Exact Mass | 660.28669290 |
| PubChem CID | 168438028 |
| InChIKey | ZWMZNCKRGUDPLZ-FEFKUCBWSA-N |
| Synonyms | 5'-O-DMT-2'-O-TBDMS-Pseudouridine; protected pseudouridine nucleoside; CAS 144429-56-1 |
| Purity | >=98.0% (HPLC) |
Storage conditions
-15 to -25 C
Technical attributes
- Material class
- Protected pseudouridine nucleoside
- Nucleoside identity
- Pseudouridine
- 2'-O protection
- TBDMS
- 5'-O protection
- DMT
- Packaging
- Custom packaging on request
Application context
- Protected nucleoside intermediate: CAS 144429-56-1 and PubChem CID 168438028 support a 5'-O-DMT, 2'-O-TBDMS protected pseudouridine nucleoside identity.
- DMT/TBDMS-protected derivative work: the DMT and TBDMS protecting groups make this entry relevant to research workflows that require protected pseudouridine derivatives.
- Derivative distinction: formula C36H44N2O8Si and InChIKey ZWMZNCKRGUDPLZ-FEFKUCBWSA-N help distinguish CH70335 from CE phosphoramidite derivatives.
Additional material information
Uses
Use this catalog entry for research-oriented identity matching, protected pseudouridine derivative work, and catalog searches involving DMT/TBDMS-protected pseudouridine.
Characteristics
5'-O-DMT-2'-O-TBDMS-pseudouridine is represented here as a protected modified nucleoside. Use the CAS number, PubChem CID, formula, exact mass, and InChIKey when aligning this entry with product specifications.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 168438028
PubChem · CID 168438028
Frequently Asked Questions
What is 5'-O-DMT-2'-O-TBDMS-pseudouridine?
It is catalog CH70335. PubChem resolves CAS 144429-56-1 to CID 168438028, with formula C36H44N2O8Si and molecular weight 660.8.
Is CH70335 a CE phosphoramidite?
No. The PubChem-supported identity for CH70335 is a protected pseudouridine nucleoside, not a CE phosphoramidite derivative.
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