L-rG (iBu) CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C50H68N7O9PSi
- MW
- 970.2
- Purity
- >=98%
L-rG (iBu) CE Phosphoramidite is a mirror-image RNA building block: 5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-2'-O-(tert-butyldimethylsilyl)-L-guanosine 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite. It is identified by CAS 679809-76-8, molecular formula C50H68N7O9PSi, molecular weight 970.2, PubChem CID 172909778, and InChIKey PGJKESPHANLWME-ZEXYNXKFSA-N.
It is the enantiomer of the natural D-guanosine amidite — built on L-ribose rather than D-ribose — so it has the same molecular formula and weight as its D-counterpart. The cited mirror-image oligonucleotide literature provides background for L-configured oligonucleotide chemistry and D/L strand-pairing orthogonality. The 2'-O-TBDMS group protects the 2'-hydroxyl, the 5'-DMT is removed each cycle, and the N2-isobutyryl base-protecting group is removed during final deprotection.
Synonyms
5'-O-DMT-N2-iBu-2'-O-TBDMS-L-guanosine 3'-CE phosphoramidite; L-riboguanosine (mirror-image) amidite
Identity and specifications
| Catalog No. | CH65088 |
| CAS No. | 679809-76-8 |
| Molecular Formula | C50H68N7O9PSi |
| Molecular Weight | 970.2 |
| PubChem CID | 172909778 |
| InChIKey | PGJKESPHANLWME-ZEXYNXKFSA-N |
| Purity | >=98% |
Storage conditions
-20 C
Technical attributes
- Monomer class
- 2'-O-TBDMS L-RNA CE phosphoramidite
- Nucleobase
- Guanine
- Sugar configuration
- L-ribose
- Base protection
- N2-isobutyryl
- Grade
- N (Normal)
- Packaging
- 50 mg; 100 mg; 250 mg; 1 g; 25 g; 100 g; 500 g; 1 kg; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
Application context
- Mirror-image (L-ribose) monomer: provides the L-guanosine subunit identity for L-RNA synthesis.
- Mirror-image literature context: cited literature supports L-configured oligonucleotide chemistry and D/L strand-pairing orthogonality.
- RNA protection scheme: 2'-O-TBDMS protects the 2'-hydroxyl, the 5'-DMT is removed each cycle, and the N2-isobutyryl base-protecting group is removed during final deprotection.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 172909778
PubChem · CID 172909778
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