2'-O-Propargyl-uridine
1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]pyrimidine-2,4-dione
Product summary
Quick view
- Product family
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemical Name
- 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]pyrimidine-2,4-dione
- MF
- C12H14N2O6
- MW
- 282.25
- Purity
- 99% (HPLC)
2'-O-Propargyl-uridine is a modified uridine nucleoside bearing a 2'-O-propargyl sugar substituent. Key identifiers include CAS 129778-58-1, molecular formula C12H14N2O6, molecular weight 282.25, and PubChem CID 15747441.
The 2'-O-propargyl group provides a terminal alkyne handle, placing this nucleoside in click-compatible oligonucleotide research contexts, including propargyl uridine-based RNA analogue chemistry. It should be presented as a modified nucleoside/reference compound, not as a protected CE phosphoramidite monomer.
Synonyms
2'-O-propargyluridine; 2'-O-propargyl uridine
Identity and specifications
| Catalog No. | CH70070 |
| CAS No. | 129778-58-1 |
| Molecular Formula | C12H14N2O6 |
| Molecular Weight | 282.25 |
| Exact Mass | 282.08518617 |
| PubChem CID | 15747441 |
| InChIKey | SJIYVXTZWZSVLZ-QCNRFFRDSA-N |
| Structural Note | Uridine nucleoside with a 2'-O-propargyl sugar modification |
| Purity | 99% (HPLC) |
Storage conditions
<-15 C; keep container tightly closed
Technical attributes
- Material class
- 2'-O-propargyl nucleoside
- Nucleobase
- Uracil
- Sugar modification
- 2'-O-propargyl
- Conjugation handle
- Terminal alkyne
- Grade
- N (Normal)
- Packaging
- 5 mg; 10 mg; 25 mg; 100 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 1 kg; 10 kg; 25 kg; 50 kg; Custom packaging on request
- Physical form
- White powder
Application context
- Click-compatible oligonucleotide chemistry: 2'-O-propargyl nucleoside chemistry is reported in enzymatic oligonucleotide preparation, DNA click-modification, and propargyl uridine-based RNA analogue contexts.
- Alkyne-handle nucleoside: the 2'-O-propargyl substituent provides a terminal alkyne handle for structure-aware click-chemistry research workflows.
- Modified-uridine reference: use as a structure and identifier reference for 2'-O-propargyl uridine chemistry.
Related technical resources
Oligonucleotide Modification
Sugar, base, backbone, terminal, and conjugation modifications for ASO, siRNA, guide RNA, aptamer, and research or labeling oligo projects.
Oligonucleotide Synthesis
Support for modified monomers, supports, sulfurizing reagents, cap analogs, and related oligo synthesis inputs.
Public references
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem Compound 15747441
PubChem · CID 15747441
Frequently Asked Questions
What is 2'-O-Propargyl-uridine?
It is a modified uridine nucleoside bearing a 2'-O-propargyl sugar substituent. PubChem confirms CAS 129778-58-1 as CID 15747441.
What does the propargyl group add?
The 2'-O-propargyl group provides a terminal alkyne handle, which places this type of nucleoside in click-compatible oligonucleotide and RNA analogue chemistry contexts.
Is CH70070 a phosphoramidite monomer?
No. CH70070 is documented as the modified nucleoside 2'-O-Propargyl-uridine. A protected CE phosphoramidite would require separate structural evidence and identifiers.
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