DOTAP
化学名称
2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl-trimethylazanium chloride
DOTAP•LNP
Structure: 
产品编号
CH51014
CAS
132172-61-3
分子式
C42H80ClNO4
分子量
698.56
规格标准
| Catalog No. | CH51014 |
| CAS No. | 132172-61-3 |
| Molecular Formula | C42H80ClNO4 |
| Molecular Weight | 698.56 |
品类工艺支持
CHEMOS supports custom synthesis and process development for LNP lipid components, with work planned according to target structure, requested scale, and analytical requirements. Ionizable lipid route development : route scouting, impurity review, stereochemistry control, and purification planning. Helper lipid and PEG-lipid preparation : support for phospholipids, sterol-related components, PEG-lipids, and related analogs. Analytical support : HPLC, NMR, MS, Karl Fischer water content, elemental analysis, and residual-solvent testing can be discussed by project. Scale-up support : transfer from laboratory preparation to larger pilot or production batches after route and quality review. Project documentation : batch-specific COA and technical information are provided according to the confirmed specification.
概况
DOTAP (also known as 2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl-trimethylazanium chloride) (CAS 132172-61-3, MF C42H80ClNO4, MW 698.56) is an ionizable lipid analog studied in lipid nanoparticle (LNP) formulations for nucleic acid delivery research, including mRNA and siRNA platforms. Practical chemistry topics around this compound include head-group structure, ester or amine linker chemistry, and tail unsaturation. Custom synthesis, process scale-up and supply planning are available through CHEMOS R&D and manufacturing facilities.
应用
- DOTAP (132172-61-3) supply and analog preparation for research programs
- Analytical method development for ionizable lipid related substances
- Ionizable lipid library and head-group / tail analog screening
- Custom analog synthesis with controlled head-group and tail variants