DOTMA
化学名称
2,3-bis[(E)-octadec-9-enoxy]propyl-trimethylazanium chloride
DOTMA•LNP
Structure: 
产品编号
CH51032
CAS
104872-42-6
分子式
C42H84ClNO2
分子量
670.59
规格标准
| Catalog No. | CH51032 |
| CAS No. | 104872-42-6 |
| Molecular Formula | C42H84ClNO2 |
| Molecular Weight | 670.59 |
品类工艺支持
CHEMOS supports custom synthesis and process development for LNP lipid components, with work planned according to target structure, requested scale, and analytical requirements. Ionizable lipid route development : route scouting, impurity review, stereochemistry control, and purification planning. Helper lipid and PEG-lipid preparation : support for phospholipids, sterol-related components, PEG-lipids, and related analogs. Analytical support : HPLC, NMR, MS, Karl Fischer water content, elemental analysis, and residual-solvent testing can be discussed by project. Scale-up support : transfer from laboratory preparation to larger pilot or production batches after route and quality review. Project documentation : batch-specific COA and technical information are provided according to the confirmed specification.
概况
DOTMA (also known as 2,3-bis[(E)-octadec-9-enoxy]propyl-trimethylazanium chloride) (CAS 104872-42-6, MF C42H84ClNO2, MW 670.59) belongs to the ionizable lipid class used in LNP delivery system research for mRNA, siRNA and gene-editing cargos. Programs working with this compound usually examine the head-group / tail combination, related-substance profile, and stereochemistry. Project scale-up and custom synthesis are coordinated by the CHEMOS R&D team across laboratory and production sites.
应用
- DOTMA (CAS 104872-42-6) preparation, route refinement, and analytical-control planning
- Ionizable lipid library and head-group / tail analog screening
- Custom analog synthesis with controlled head-group and tail variants
- Analytical method development for ionizable lipid related substances