DOTA-bis(tert-butyl)ester
化学名称
2-[7-(carboxymethyl)-4,10-bis[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
DOTA-bis(tert-butyl)ester•DOTA
Structure: 
产品编号
CH54017
CAS
913542-71-9
分子式
C24H44N4O8
分子量
516.63
规格标准
| Catalog No. | CH54017 |
| CAS No. | 913542-71-9 |
| Molecular Formula | C24H44N4O8 |
| Molecular Weight | 516.63 |
品类工艺支持
CHEMOS supports DOTA chelator and radiopharmaceutical building-block chemistry, including protected, activated, PEG-spaced, and conjugation-ready intermediates. DOTA and DOTA-GA derivatives : protected chelators, activated esters, maleimide derivatives, and linker-spaced variants. Custom chelator-linker synthesis : route design for chelator-linker-targeting moiety intermediates. Metal-sensitive process control : purification and analytical planning for low-metal-background requirements. Analytical support : HPLC, NMR, MS, and ICP-MS can be discussed according to project needs. Scale-up support : process optimization and batch-size planning after technical review.
概况
DOTA-bis(tert-butyl)ester (also known as 2-[7-(carboxymethyl)-4,10-bis[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid) (CAS 913542-71-9, MF C24H44N4O8, MW 516.63) is a DOTA-family macrocyclic chelator building block used in radiopharmaceutical and metal-conjugate research. Programs working with this compound typically focus on selective functionalisation, radiometal compatibility (e.g., ⁹⁰Y, ¹⁷⁷Lu, ⁶⁴Cu), and conjugate stability. Project scale-up and custom synthesis are coordinated by the CHEMOS R&D team across laboratory and production sites.
应用
- DOTA-bis(tert-butyl)ester (913542-71-9) supply and analog preparation for research programs
- Antibody and peptide radiolabeling research
- DOTA-conjugate analog synthesis (e.g., DOTATATE-family research)
- Custom synthesis of mono-functionalised DOTA derivatives