MMT-C6-Amine-Linker Phosphoramidite
Oligonucleotide Conjugation & Delivery Ligands
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Conjugation & Delivery Ligands
- MF
- C35H48N3O3P
- MW
- 589.7
- Reinheit
- >=99.5% (HPLC)
MMT-C6-Amine-Linker Phosphoramidite is a non-nucleoside modifier for adding a reactive amino group to an oligonucleotide: a six-carbon (hexyl) linker carrying a monomethoxytrityl (MMT)-protected primary amine at one end and a (2-cyanoethyl N,N-diisopropyl)phosphoramidite at the other. Its PubChem-backed identity includes CAS 114616-27-2, molecular formula C35H48N3O3P, molecular weight 589.7, and PubChem CID 9873234.
Coupling attaches an aminohexyl arm to the oligonucleotide (typically the 5'-terminus). The acid-labile MMT group protects the amine during synthesis and is removed afterward to reveal a free primary amine on a C6 spacer. The cited amino-modifier literature describes aliphatic amino groups reacting with electrophiles, allowing dyes, biotin, or other chemical species to be attached to oligonucleotides.
Synonyme
5'-Amino-Modifier C6; 6-(MMT-amino)hexyl-(2-cyanoethyl)-(N,N-diisopropyl)phosphoramidite
Identität und Spezifikationen
| Catalog No. | CH65104 |
| CAS No. | 114616-27-2 |
| Molecular Formula | C35H48N3O3P |
| Molecular Weight | 589.7 |
| PubChem CID | 9873234 |
| InChIKey | YBANXOPIYSVPMH-UHFFFAOYSA-N |
| Purity | >=99.5% (HPLC) |
Lagerbedingungen
-20 C
Technische Merkmale
- Modifier type
- Non-nucleoside amino-modifier phosphoramidite
- Spacer
- C6 (hexyl)
- Protecting group
- MMT (monomethoxytrityl), acid-labile
- Exposed handle
- Primary amine after MMT removal
- Grade
- N (Normal)
- Packaging
- 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 2 g; 5 g; 10 g; 25 g; 50 g; 100 g; 500 g; 1 kg; 5 kg; 100 µmol; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- colorless oily liquid
- Stability
- Acetonitrile solution: use within 24 hours
Anwendungskontext
- Amino conjugation handle: provides a primary amine on a six-carbon spacer at the oligonucleotide terminus.
- Electrophile-reactive amine: the cited literature describes aliphatic amino groups reacting with electrophiles to attach dyes, biotin, or other species.
- MMT-protected during synthesis: the acid-labile MMT group masks the amine during assembly and is removed to expose it afterward.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency in mice
Nucleic Acids Research, 2014
Product-family technical context
- Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits RNAi-mediated gene silencing
Journal of the American Chemical Society, 2014
Product-family technical context
- siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes
ACS Chemical Biology, 2015
Product-family technical context
- Comparative Characterization of Hepatic Distribution and mRNA Reduction of Antisense Oligonucleotides Conjugated with Triantennary N-Acetyl Galactosamine and Lipophilic Ligands
Journal of Pharmacology and Experimental Therapeutics, 2016
Product-family technical context
- PubChem-Verbindung 9873234
PubChem · CID 9873234
Häufig gestellte Fragen
What does this amino-linker do?
It provides a primary amine on a six-carbon spacer at an oligonucleotide terminus. After the MMT protecting group is removed, the amine can react with electrophiles to attach dyes, biotin, or other conjugates.
Why is the amine MMT-protected?
The monomethoxytrityl (MMT) group masks the reactive amine during solid-phase synthesis. It is acid-labile and removed afterward to reveal the free primary amine for conjugation.
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