2'-O-C16-A (Bz) Phosphoramidite
Oligonucleotide Conjugation & Delivery Ligands
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Conjugation & Delivery Ligands
- MF
- C63H84N7O8P
- MW
- 1098.4
- Reinheit
- 99.98%
2'-O-C16-A (Bz) Phosphoramidite is a lipophilic 2'-modified RNA building block: 5'-O-(4,4'-dimethoxytrityl)-N6-benzoyladenosine with a 2'-O-hexadecyl (C16) group and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite. Its PubChem-backed identity includes CAS 2382942-35-8, molecular formula C63H84N7O8P, molecular weight 1098.4, and PubChem CID 167312663.
The 2'-O-C16 chain is a permanent 2'-O-modification — a long, fatty-acid-type lipophilic substituent rather than a protecting group. The cited 2'-modification literature discusses 2'-position sugar modifications in relation to nuclease/metabolic stability, and cited lipophilic-oligonucleotide literature discusses fatty-acid-type moieties in relation to lipid-particle and plasma-protein affinity. The monomer couples through a standard 3'-phosphoramidite (3'→5' linkages), the 5'-DMT is removed each cycle, and N6-benzoyl protection is removed during final deprotection.
Synonyme
5'-O-DMT-N6-Bz-2'-O-hexadecyladenosine 3'-CE phosphoramidite; 2'-O-C16 (palmityl-type) adenosine amidite
Identität und Spezifikationen
| Catalog No. | CH65107 |
| CAS No. | 2382942-35-8 |
| Molecular Formula | C63H84N7O8P |
| Molecular Weight | 1098.4 |
| PubChem CID | 167312663 |
| InChIKey | JEFOGZDZKKCGEJ-OSIIFERKSA-N |
| Purity | 99.98% |
Lagerbedingungen
-20 C
Technische Merkmale
- Modifier type
- Lipophilic nucleoside phosphoramidite
- Nucleoside scaffold
- Adenosine
- 2'-O substituent
- Hexadecyl (C16)
- Base protection
- N6-Benzoyl
- Packaging
- 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 2 g; 5 g; 10 g; 50 g; 100 g; 500 g; 1 kg; 5 kg; 10 kg; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
- Stability
- 2 years under stated storage
Anwendungskontext
- Lipophilic 2'-O-C16 modification: provides a long hexadecyl (C16) chain at the 2'-position — a permanent, fatty-acid-type lipophilic substituent.
- Cited 2'-modification context: the cited literature discusses 2'-position sugar modifications in relation to nuclease/metabolic stability.
- Cited lipophilic-moiety context: the cited literature discusses fatty-acid-type moieties in relation to lipid-particle and plasma-protein affinity.
- 3'→5' coupling monomer: couples through a 3'-phosphoramidite; 5'-DMT is removed each cycle; N6-benzoyl protection is removed during final deprotection.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency in mice
Nucleic Acids Research, 2014
Product-family technical context
- Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits RNAi-mediated gene silencing
Journal of the American Chemical Society, 2014
Product-family technical context
- siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes
ACS Chemical Biology, 2015
Product-family technical context
- Comparative Characterization of Hepatic Distribution and mRNA Reduction of Antisense Oligonucleotides Conjugated with Triantennary N-Acetyl Galactosamine and Lipophilic Ligands
Journal of Pharmacology and Experimental Therapeutics, 2016
Product-family technical context
- PubChem-Verbindung 167312663
PubChem · CID 167312663
Häufig gestellte Fragen
What is the 2'-O-C16 modification?
It is a 2'-O-hexadecyl group — a long, fatty-acid-type lipophilic chain permanently attached at the 2'-position. It is not a protecting group; it stays on the finished oligonucleotide.
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