Sulfo-SMCC sodium
Sulfo-SMCC sodium
Resumen del producto
Vista rápida
- Familia de productos
- ADC Linkers & Conjugation Reagents
- Nombre químico
- Sulfo-SMCC sodium
- FM
- C16H17N2NaO9S
- PM
- 436.37
Sulfo-SMCC sodium is a water-soluble SMCC-type crosslinker identified by CAS 92921-24-9.
PubChem CID 4618794 and ChemicalBook support molecular formula C16H17N2NaO9S; ChemicalBook lists molecular weight 436.37, while PubChem rounds it as 436.4.
The page presents the compound through its sodium sulfonate, NHS ester, and maleimide functional-group context for research bioconjugation work.
Identidad y especificaciones
| Catalog No. | CH53019 |
| CAS No. | 92921-24-9 |
| Product Name | Sulfo-SMCC sodium |
| Synonyms | Sulfo-SMCC; Sulfo-SMCC sodium salt; Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt |
| Molecular Formula | C16H17N2NaO9S |
| Molecular Weight | 436.37 |
| PubChem CID | 4618794 |
| InChIKey | VUFNRPJNRFOTGK-UHFFFAOYSA-M |
| IUPAC Name | sodium 1-[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]oxy-2,5-dioxopyrrolidine-3-sulfonate |
Contexto de aplicación
- Crosslinker identity reference: matches Sulfo-SMCC sodium, Sulfo-SMCC, and sulfosuccinimidyl SMCC naming to CAS 92921-24-9.
- Bioconjugation research: PubMed and ChemicalBook sources describe Sulfo-SMCC in protein crosslinking and conjugation research.
- Functional-group comparison: useful for comparing NHS ester and maleimide crosslinker records in research-planning materials.
Información adicional del material
Usos
Sulfo-SMCC sodium is a water-soluble SMCC-type research crosslinker identified by CAS 92921-24-9. Its NHS ester and maleimide groups make it relevant to crosslinker comparison and conjugation-method references.
Características
- Sodium sulfonate form of an SMCC-type crosslinker.
- Contains NHS ester and maleimide functional groups in the same molecule.
- Formula C16H17N2NaO9S is consistent across PubChem and ChemicalBook.
Recursos técnicos relacionados
Química de enlazadores y cargas para ADC
Enlazadores escindibles o estables, espaciadores hidrofílicos, grupos reactivos selectivos e intermedios carga-enlazador.
Enlazadores ADC escindibles y no escindibles
Comparación según la especie liberada, el mecanismo de activación, la estabilidad en circulación, el procesamiento celular, la carga molecular, la conjugación y la evidencia analítica.
Fuentes públicas
- Sulfo-SMCC sodium | PubChem CID 4618794
- Development of Solid-Phase Site-Specific Conjugation and Its Application toward Generation of Dual Labeled Antibody and Fab Drug Conjugates
Bioconjugate Chemistry, 2016
Product-family technical context
- Effect of Linker-Drug Properties and Conjugation Site on the Physical Stability of ADCs
Journal of Pharmaceutical Sciences, 2020
Product-family technical context
- Antibody-Maytansinoid Conjugates Are Activated in Targeted Cancer Cells by Lysosomal Degradation and Linker-Dependent Intracellular Processing
Cancer Research, 2006
Product-family technical context
- The Effect of Different Linkers on Target Cell Catabolism and Pharmacokinetics/Pharmacodynamics of Trastuzumab Maytansinoid Conjugates
Molecular Cancer Therapeutics, 2012
Product-family technical context
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