CHEMOS
Bis-PEG6-NHS ester

Bis-PEG6-NHS ester

Chemical Name

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

Bis-PEG6-NHS ester•ADC linker
Structure: Bis-PEG6-NHS ester structure, CAS 1526718-98-8, MW 576.55
Product No
CH53006
CAS
1526718-98-8
MF
C24H36N2O14
MW
576.55
Specification
Catalog No.CH53006
CAS No.1526718-98-8
Molecular FormulaC24H36N2O14
Molecular Weight576.55

CHEMOS Support for This Category

CHEMOS supports ADC linker and bioconjugation building-block projects from route design through custom synthesis and process optimization. Custom linker synthesis : peptide, PEG, self-immolative, cleavable, and non-cleavable linker structures. Functional-handle installation : NHS ester, maleimide, azide, alkyne, and other conjugation-ready groups. Multi-step route development : protecting-group strategy, coupling optimization, purification review, and impurity-profile control. Analytical support : HPLC, NMR, MS, and chiral methods where applicable. Scale-up planning : laboratory-to-production transfer can be evaluated after route feasibility and specification review.

Overview

Bis-PEG6-NHS ester (also known as (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate) (CAS 1526718-98-8, MF C24H36N2O14, MW 576.55) is an antibody-drug conjugate (ADC) linker or bioconjugation building block. Chemistry topics around such compounds typically cover the reactive handle (maleimide / NHS / DBCO / azide), linker stability in plasma, and release behaviour intracellularly. Custom synthesis, process scale-up and supply planning are available through CHEMOS R&D and manufacturing facilities.

Applications

  • Bis-PEG6-NHS ester (CAS 1526718-98-8) preparation, route refinement, and analytical-control planning
  • Bioconjugation handle for site-specific cysteine / lysine attachment
  • Cleavable peptide-linker design and intracellular-release studies
  • Click-chemistry coupling (DBCO / azide) for bioconjugation programs

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