CHEMOS
Boc-Val-Ala-PAB-PNP

Boc-Val-Ala-PAB-PNP

Chemical Name

[4-[[(2S)-2-[[(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]amino]propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate

Boc-Val-Ala-PAB-PNP•ADC linker
Structure: Boc-Val-Ala-PAB-PNP structure, CAS 1884578-00-0, MW 558.58
Product No
CH53008
CAS
1884578-00-0
MF
C27H34N4O9
MW
558.58
Specification
Catalog No.CH53008
CAS No.1884578-00-0
Molecular FormulaC27H34N4O9
Molecular Weight558.58

CHEMOS Support for This Category

CHEMOS supports ADC linker and bioconjugation building-block projects from route design through custom synthesis and process optimization. Custom linker synthesis : peptide, PEG, self-immolative, cleavable, and non-cleavable linker structures. Functional-handle installation : NHS ester, maleimide, azide, alkyne, and other conjugation-ready groups. Multi-step route development : protecting-group strategy, coupling optimization, purification review, and impurity-profile control. Analytical support : HPLC, NMR, MS, and chiral methods where applicable. Scale-up planning : laboratory-to-production transfer can be evaluated after route feasibility and specification review.

Overview

Boc-Val-Ala-PAB-PNP (also known as [4-[[(2S)-2-[[(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]amino]propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate) (CAS 1884578-00-0, MF C27H34N4O9, MW 558.58) belongs to the ADC linker / bioconjugation handle class. Practical chemistry questions involve the conjugation chemistry, peptide-cleavable element design (where applicable), and analytical control of related impurities. Project scale-up and custom synthesis are coordinated by the CHEMOS R&D team across laboratory and production sites.

Applications

  • Boc-Val-Ala-PAB-PNP (CAS 1884578-00-0) preparation, route refinement, and analytical-control planning
  • Cleavable peptide-linker design and intracellular-release studies
  • Custom linker / payload-linker synthesis on request
  • Antibody-drug conjugate (ADC) linker chemistry research

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