SMCC crosslinker
Chemical Name
(2,5-dioxopyrrolidin-1-yl) 4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexane-1-carboxylate
SMCC crosslinker•ADC linker
Structure: 
Product No
CH53015
CAS
64987-85-5
MF
C16H18N2O6
MW
334.32
Specification
| Catalog No. | CH53015 |
| CAS No. | 64987-85-5 |
| Molecular Formula | C16H18N2O6 |
| Molecular Weight | 334.32 |
CHEMOS Support for This Category
CHEMOS supports ADC linker and bioconjugation building-block projects from route design through custom synthesis and process optimization. Custom linker synthesis : peptide, PEG, self-immolative, cleavable, and non-cleavable linker structures. Functional-handle installation : NHS ester, maleimide, azide, alkyne, and other conjugation-ready groups. Multi-step route development : protecting-group strategy, coupling optimization, purification review, and impurity-profile control. Analytical support : HPLC, NMR, MS, and chiral methods where applicable. Scale-up planning : laboratory-to-production transfer can be evaluated after route feasibility and specification review.
Overview
SMCC crosslinker (also known as (2,5-dioxopyrrolidin-1-yl) 4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexane-1-carboxylate) (CAS 64987-85-5, MF C16H18N2O6, MW 334.32) is used as a linker / reactive-handle building block in ADC and bioconjugation research. Programs working with this compound usually examine selectivity of the bioconjugation chemistry, linker stability, and downstream payload release. Custom synthesis, process scale-up and supply planning are available through CHEMOS R&D and manufacturing facilities.
Applications
- SMCC crosslinker (CAS 64987-85-5) route review and custom analog preparation
- Cleavable peptide-linker design and intracellular-release studies
- Click-chemistry coupling (DBCO / azide) for bioconjugation programs
- Custom linker / payload-linker synthesis on request
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