CHEMOS
DBCO-NHS ester

DBCO-NHS ester

Chemical Name

(2,5-dioxopyrrolidin-1-yl) 4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoate

DBCO-NHS ester•ADC linker
Structure: DBCO-NHS ester structure, CAS 1353016-71-3, MW 402.4
Product No
CH53017
CAS
1353016-71-3
MF
C23H18N2O5
MW
402.4
Specification
Catalog No.CH53017
CAS No.1353016-71-3
Molecular FormulaC23H18N2O5
Molecular Weight402.4

CHEMOS Support for This Category

CHEMOS supports ADC linker and bioconjugation building-block projects from route design through custom synthesis and process optimization. Custom linker synthesis : peptide, PEG, self-immolative, cleavable, and non-cleavable linker structures. Functional-handle installation : NHS ester, maleimide, azide, alkyne, and other conjugation-ready groups. Multi-step route development : protecting-group strategy, coupling optimization, purification review, and impurity-profile control. Analytical support : HPLC, NMR, MS, and chiral methods where applicable. Scale-up planning : laboratory-to-production transfer can be evaluated after route feasibility and specification review.

Overview

DBCO-NHS ester (also known as (2,5-dioxopyrrolidin-1-yl) 4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoate) (CAS 1353016-71-3, MF C23H18N2O5, MW 402.4) belongs to the ADC linker / bioconjugation handle class. Practical chemistry questions involve the conjugation chemistry, peptide-cleavable element design (where applicable), and analytical control of related impurities. Project scale-up and custom synthesis are coordinated by the CHEMOS R&D team across laboratory and production sites.

Applications

  • DBCO-NHS ester (CAS 1353016-71-3) route review and custom analog preparation
  • Process-development support for scalable linker preparation
  • Antibody-drug conjugate (ADC) linker chemistry research
  • Bioconjugation handle for site-specific cysteine / lysine attachment

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