CHEMOS
Mc-Val-Cit-PABC-PNP

Mc-Val-Cit-PABC-PNP

Chemical Name

[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate

Mc-Val-Cit-PABC-PNP•ADC linker
Structure: Mc-Val-Cit-PABC-PNP structure, CAS 159857-81-5, MW 737.76
Product No
CH53018
CAS
159857-81-5
MF
C35H43N7O11
MW
737.76
Specification
Catalog No.CH53018
CAS No.159857-81-5
Molecular FormulaC35H43N7O11
Molecular Weight737.76

CHEMOS Support for This Category

CHEMOS supports ADC linker and bioconjugation building-block projects from route design through custom synthesis and process optimization. Custom linker synthesis : peptide, PEG, self-immolative, cleavable, and non-cleavable linker structures. Functional-handle installation : NHS ester, maleimide, azide, alkyne, and other conjugation-ready groups. Multi-step route development : protecting-group strategy, coupling optimization, purification review, and impurity-profile control. Analytical support : HPLC, NMR, MS, and chiral methods where applicable. Scale-up planning : laboratory-to-production transfer can be evaluated after route feasibility and specification review.

Overview

Mc-Val-Cit-PABC-PNP (also known as [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate) (CAS 159857-81-5, MF C35H43N7O11, MW 737.76) belongs to the ADC linker / bioconjugation handle class. Practical chemistry questions involve the conjugation chemistry, peptide-cleavable element design (where applicable), and analytical control of related impurities. CHEMOS process chemistry, organic synthesis routes and project scale-up support are offered for downstream programs.

Applications

  • Mc-Val-Cit-PABC-PNP (159857-81-5) as a starting point for downstream chemistry programs
  • Bioconjugation handle for site-specific cysteine / lysine attachment
  • Cleavable peptide-linker design and intracellular-release studies
  • Click-chemistry coupling (DBCO / azide) for bioconjugation programs

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