CHEMOS
DOTA-NHS-ester

DOTA-NHS-ester

Chemical Name

2-[4,10-bis(carboxymethyl)-7-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid

DOTA-NHS-ester•ADC linker
Structure: DOTA-NHS-ester structure, CAS 170908-81-3, MW 501.49
Product No
CH53020
CAS
170908-81-3
MF
C20H31N5O10
MW
501.49
Specification
Catalog No.CH53020
CAS No.170908-81-3
Molecular FormulaC20H31N5O10
Molecular Weight501.49

CHEMOS Support for This Category

CHEMOS supports ADC linker and bioconjugation building-block projects from route design through custom synthesis and process optimization. Custom linker synthesis : peptide, PEG, self-immolative, cleavable, and non-cleavable linker structures. Functional-handle installation : NHS ester, maleimide, azide, alkyne, and other conjugation-ready groups. Multi-step route development : protecting-group strategy, coupling optimization, purification review, and impurity-profile control. Analytical support : HPLC, NMR, MS, and chiral methods where applicable. Scale-up planning : laboratory-to-production transfer can be evaluated after route feasibility and specification review.

Overview

DOTA-NHS-ester (also known as 2-[4,10-bis(carboxymethyl)-7-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid) (CAS 170908-81-3, MF C20H31N5O10, MW 501.49) belongs to the ADC linker / bioconjugation handle class. Practical chemistry questions involve the conjugation chemistry, peptide-cleavable element design (where applicable), and analytical control of related impurities. CHEMOS process chemistry, organic synthesis routes and project scale-up support are offered for downstream programs.

Applications

  • DOTA-NHS-ester (CAS 170908-81-3) preparation, route refinement, and analytical-control planning
  • Cleavable peptide-linker design and intracellular-release studies
  • Click-chemistry coupling (DBCO / azide) for bioconjugation programs
  • Custom linker / payload-linker synthesis on request

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