CHEMOS
DOTA-tri(t-butyl ester)

DOTA-tri(t-butyl ester)

Chemical Name

2-[4,7,10-tris[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid

DOTA-tri(t-butyl ester)•DOTA
Structure: DOTA-tri(t-butyl ester) structure, CAS 137076-54-1, MW 572.73
Product No
CH54001
CAS
137076-54-1
MF
C28H52N4O8
MW
572.73
Specification
Catalog No.CH54001
CAS No.137076-54-1
Molecular FormulaC28H52N4O8
Molecular Weight572.73

CHEMOS Support for This Category

CHEMOS supports DOTA chelator and radiopharmaceutical building-block chemistry, including protected, activated, PEG-spaced, and conjugation-ready intermediates. DOTA and DOTA-GA derivatives : protected chelators, activated esters, maleimide derivatives, and linker-spaced variants. Custom chelator-linker synthesis : route design for chelator-linker-targeting moiety intermediates. Metal-sensitive process control : purification and analytical planning for low-metal-background requirements. Analytical support : HPLC, NMR, MS, and ICP-MS can be discussed according to project needs. Scale-up support : process optimization and batch-size planning after technical review.

Overview

DOTA-tri(t-butyl ester) (also known as 2-[4,7,10-tris[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid) (CAS 137076-54-1, MF C28H52N4O8, MW 572.73) belongs to the DOTA-family chelator class for targeted radiopharmaceutical research. Programs typically examine residual metal control, kinetic inertness of the metal complex, and the available coupling handle. CHEMOS process-development team and large production base can support route refinement, scale-up and custom synthesis on request.

Applications

  • DOTA-tri(t-butyl ester) (CAS 137076-54-1) route review and custom analog preparation
  • Process-development support for scalable chelator preparation
  • Targeted radioligand therapy (TRT) building block — ⁹⁰Y / ¹⁷⁷Lu / ²²⁵Ac conjugates
  • DOTA-conjugate analog synthesis (e.g., DOTATATE-family research)

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