CHEMOS
NH2-PEG4-DOTA

NH2-PEG4-DOTA

Chemical Name

2-[4-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid

NH2-PEG4-DOTA•DOTA
Structure: NH2-PEG4-DOTA structure, CAS 2090232-34-9, MW 622.71
Product No
CH54004
CAS
2090232-34-9
MF
C26H50N6O11
MW
622.71
Specification
Catalog No.CH54004
CAS No.2090232-34-9
Molecular FormulaC26H50N6O11
Molecular Weight622.71

CHEMOS Support for This Category

CHEMOS supports DOTA chelator and radiopharmaceutical building-block chemistry, including protected, activated, PEG-spaced, and conjugation-ready intermediates. DOTA and DOTA-GA derivatives : protected chelators, activated esters, maleimide derivatives, and linker-spaced variants. Custom chelator-linker synthesis : route design for chelator-linker-targeting moiety intermediates. Metal-sensitive process control : purification and analytical planning for low-metal-background requirements. Analytical support : HPLC, NMR, MS, and ICP-MS can be discussed according to project needs. Scale-up support : process optimization and batch-size planning after technical review.

Overview

NH2-PEG4-DOTA (also known as 2-[4-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid) (CAS 2090232-34-9, MF C26H50N6O11, MW 622.71) is part of the DOTA chelator family used in targeted radioligand and imaging-conjugate research. Practical chemistry topics include mono-functionalisation of the macrocycle, protection-group strategy, and conjugation chemistry with peptides or antibodies. Project scale-up and custom synthesis are coordinated by the CHEMOS R&D team across laboratory and production sites.

Applications

  • NH2-PEG4-DOTA (CAS 2090232-34-9) preparation, route refinement, and analytical-control planning
  • Antibody and peptide radiolabeling research
  • Custom synthesis of mono-functionalised DOTA derivatives
  • Trace-metal control studies for radiopharmaceutical conjugates

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