CHEMOS
DOTAGA-anhydride

DOTAGA-anhydride

Chemical Name

2-[4,10-bis(carboxymethyl)-7-(2,6-dioxooxan-3-yl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid

DOTAGA-anhydride•DOTA
Structure: DOTAGA-anhydride structure, CAS 1375475-53-8, MW 458.46
Product No
CH54002
CAS
1375475-53-8
MF
C19H30N4O9
MW
458.46
Specification
Catalog No.CH54002
CAS No.1375475-53-8
Molecular FormulaC19H30N4O9
Molecular Weight458.46

CHEMOS Support for This Category

CHEMOS supports DOTA chelator and radiopharmaceutical building-block chemistry, including protected, activated, PEG-spaced, and conjugation-ready intermediates. DOTA and DOTA-GA derivatives : protected chelators, activated esters, maleimide derivatives, and linker-spaced variants. Custom chelator-linker synthesis : route design for chelator-linker-targeting moiety intermediates. Metal-sensitive process control : purification and analytical planning for low-metal-background requirements. Analytical support : HPLC, NMR, MS, and ICP-MS can be discussed according to project needs. Scale-up support : process optimization and batch-size planning after technical review.

Overview

DOTAGA-anhydride (also known as 2-[4,10-bis(carboxymethyl)-7-(2,6-dioxooxan-3-yl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid) (CAS 1375475-53-8, MF C19H30N4O9, MW 458.46) is a DOTA-family macrocyclic chelator building block used in radiopharmaceutical and metal-conjugate research. Programs working with this compound typically focus on selective functionalisation, radiometal compatibility (e.g., ⁹⁰Y, ¹⁷⁷Lu, ⁶⁴Cu), and conjugate stability. Custom synthesis, process scale-up and supply planning are available through CHEMOS R&D and manufacturing facilities.

Applications

  • DOTAGA-anhydride (CAS 1375475-53-8) preparation, route refinement, and analytical-control planning
  • Antibody and peptide radiolabeling research
  • DOTA-conjugate analog synthesis (e.g., DOTATATE-family research)
  • Custom synthesis of mono-functionalised DOTA derivatives

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