CHEMOS
2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)

2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)

Chemical Name

tert-butyl 2-[4-[2-(2-aminoethylamino)-2-oxoethyl]-7,10-bis[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetate

2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)•DOTA
Structure: 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) structure, CAS 173308-19-5, MW 614.82
Product No
CH54005
CAS
173308-19-5
MF
C30H58N6O7
MW
614.82
Specification
Catalog No.CH54005
CAS No.173308-19-5
Molecular FormulaC30H58N6O7
Molecular Weight614.82

CHEMOS Support for This Category

CHEMOS supports DOTA chelator and radiopharmaceutical building-block chemistry, including protected, activated, PEG-spaced, and conjugation-ready intermediates. DOTA and DOTA-GA derivatives : protected chelators, activated esters, maleimide derivatives, and linker-spaced variants. Custom chelator-linker synthesis : route design for chelator-linker-targeting moiety intermediates. Metal-sensitive process control : purification and analytical planning for low-metal-background requirements. Analytical support : HPLC, NMR, MS, and ICP-MS can be discussed according to project needs. Scale-up support : process optimization and batch-size planning after technical review.

Overview

2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (also known as tert-butyl 2-[4-[2-(2-aminoethylamino)-2-oxoethyl]-7,10-bis[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetate) (CAS 173308-19-5, MF C30H58N6O7, MW 614.82) is a DOTA-family macrocyclic chelator building block used in radiopharmaceutical and metal-conjugate research. Programs working with this compound typically focus on selective functionalisation, radiometal compatibility (e.g., ⁹⁰Y, ¹⁷⁷Lu, ⁶⁴Cu), and conjugate stability. Bench-scale to larger-scale production is supported through CHEMOS organic chemistry workflows and dedicated process-development resources.

Applications

  • 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (CAS 173308-19-5) preparation, route refinement, and analytical-control planning
  • Custom synthesis of mono-functionalised DOTA derivatives
  • Process-development support for scalable chelator preparation
  • Trace-metal control studies for radiopharmaceutical conjugates

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