CHEMOS
DOTA-GA-maleimide

DOTA-GA-maleimide

Chemical Name

5-[2-(2,5-dioxopyrrol-1-yl)ethylamino]-5-oxo-2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]pentanoic acid

DOTA-GA-maleimide•DOTA
Structure: DOTA-GA-maleimide structure, CAS 1800229-46-2, MW 598.61
Product No
CH54003
CAS
1800229-46-2
MF
C25H38N6O11
MW
598.61
Specification
Catalog No.CH54003
CAS No.1800229-46-2
Molecular FormulaC25H38N6O11
Molecular Weight598.61

CHEMOS Support for This Category

CHEMOS supports DOTA chelator and radiopharmaceutical building-block chemistry, including protected, activated, PEG-spaced, and conjugation-ready intermediates. DOTA and DOTA-GA derivatives : protected chelators, activated esters, maleimide derivatives, and linker-spaced variants. Custom chelator-linker synthesis : route design for chelator-linker-targeting moiety intermediates. Metal-sensitive process control : purification and analytical planning for low-metal-background requirements. Analytical support : HPLC, NMR, MS, and ICP-MS can be discussed according to project needs. Scale-up support : process optimization and batch-size planning after technical review.

Overview

DOTA-GA-maleimide (also known as 5-[2-(2,5-dioxopyrrol-1-yl)ethylamino]-5-oxo-2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]pentanoic acid) (CAS 1800229-46-2, MF C25H38N6O11, MW 598.61) is a DOTA-family macrocyclic chelator building block used in radiopharmaceutical and metal-conjugate research. Programs working with this compound typically focus on selective functionalisation, radiometal compatibility (e.g., ⁹⁰Y, ¹⁷⁷Lu, ⁶⁴Cu), and conjugate stability. CHEMOS process chemistry, organic synthesis routes and project scale-up support are offered for downstream programs.

Applications

  • DOTA-GA-maleimide (1800229-46-2) supply and analog preparation for research programs
  • Trace-metal control studies for radiopharmaceutical conjugates
  • Targeted radioligand therapy (TRT) building block — ⁹⁰Y / ¹⁷⁷Lu / ²²⁵Ac conjugates
  • Antibody and peptide radiolabeling research

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