CHEMOS
DOTA-GA(tBu)4

DOTA-GA(tBu)4

Chemical Name

5-[(2-methylpropan-2-yl)oxy]-5-oxo-4-[4,7,10-tris[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]pentanoic acid

DOTA-GA(tBu)4•DOTA
Structure: DOTA-GA(tBu)4 structure, CAS 306776-79-4, MW 700.9
Product No
CH54006
CAS
306776-79-4
MF
C35H64N4O10
MW
700.9
Specification
Catalog No.CH54006
CAS No.306776-79-4
Molecular FormulaC35H64N4O10
Molecular Weight700.9

CHEMOS Support for This Category

CHEMOS supports DOTA chelator and radiopharmaceutical building-block chemistry, including protected, activated, PEG-spaced, and conjugation-ready intermediates. DOTA and DOTA-GA derivatives : protected chelators, activated esters, maleimide derivatives, and linker-spaced variants. Custom chelator-linker synthesis : route design for chelator-linker-targeting moiety intermediates. Metal-sensitive process control : purification and analytical planning for low-metal-background requirements. Analytical support : HPLC, NMR, MS, and ICP-MS can be discussed according to project needs. Scale-up support : process optimization and batch-size planning after technical review.

Overview

DOTA-GA(tBu)4 (also known as 5-[(2-methylpropan-2-yl)oxy]-5-oxo-4-[4,7,10-tris[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]pentanoic acid) (CAS 306776-79-4, MF C35H64N4O10, MW 700.9) is part of the DOTA chelator family used in targeted radioligand and imaging-conjugate research. Practical chemistry topics include mono-functionalisation of the macrocycle, protection-group strategy, and conjugation chemistry with peptides or antibodies. Bench-scale to larger-scale production is supported through CHEMOS organic chemistry workflows and dedicated process-development resources.

Applications

  • DOTA-GA(tBu)4 (CAS 306776-79-4) route review and custom analog preparation
  • Process-development support for scalable chelator preparation
  • Trace-metal control studies for radiopharmaceutical conjugates
  • Targeted radioligand therapy (TRT) building block — ⁹⁰Y / ¹⁷⁷Lu / ²²⁵Ac conjugates

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