CHEMOS
Azido-mono-amide-DOTA

Azido-mono-amide-DOTA

Chemical Name

2-[4-[2-(3-azidopropylamino)-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid

Azido-mono-amide-DOTA•DOTA
Structure: Azido-mono-amide-DOTA structure, CAS 1227407-76-2, MW 486.53
Product No
CH54007
CAS
1227407-76-2
MF
C19H34N8O7
MW
486.53
Specification
Catalog No.CH54007
CAS No.1227407-76-2
Molecular FormulaC19H34N8O7
Molecular Weight486.53

CHEMOS Support for This Category

CHEMOS supports DOTA chelator and radiopharmaceutical building-block chemistry, including protected, activated, PEG-spaced, and conjugation-ready intermediates. DOTA and DOTA-GA derivatives : protected chelators, activated esters, maleimide derivatives, and linker-spaced variants. Custom chelator-linker synthesis : route design for chelator-linker-targeting moiety intermediates. Metal-sensitive process control : purification and analytical planning for low-metal-background requirements. Analytical support : HPLC, NMR, MS, and ICP-MS can be discussed according to project needs. Scale-up support : process optimization and batch-size planning after technical review.

Overview

Azido-mono-amide-DOTA (also known as 2-[4-[2-(3-azidopropylamino)-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid) (CAS 1227407-76-2, MF C19H34N8O7, MW 486.53) is part of the DOTA chelator family used in targeted radioligand and imaging-conjugate research. Practical chemistry topics include mono-functionalisation of the macrocycle, protection-group strategy, and conjugation chemistry with peptides or antibodies. Project scale-up and custom synthesis are coordinated by the CHEMOS R&D team across laboratory and production sites.

Applications

  • Azido-mono-amide-DOTA (1227407-76-2) supply and analog preparation for research programs
  • Antibody and peptide radiolabeling research
  • Custom synthesis of mono-functionalised DOTA derivatives
  • Trace-metal control studies for radiopharmaceutical conjugates

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