CHEMOS
Butyne-DOTA

Butyne-DOTA

Chemical Name

2-[4-[2-(but-3-ynylamino)-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid

Butyne-DOTA•DOTA
Structure: Butyne-DOTA structure, CAS 2125661-62-1, MW 455.51
Product No
CH54009
CAS
2125661-62-1
MF
C20H33N5O7
MW
455.51
Specification
Catalog No.CH54009
CAS No.2125661-62-1
Molecular FormulaC20H33N5O7
Molecular Weight455.51

CHEMOS Support for This Category

CHEMOS supports DOTA chelator and radiopharmaceutical building-block chemistry, including protected, activated, PEG-spaced, and conjugation-ready intermediates. DOTA and DOTA-GA derivatives : protected chelators, activated esters, maleimide derivatives, and linker-spaced variants. Custom chelator-linker synthesis : route design for chelator-linker-targeting moiety intermediates. Metal-sensitive process control : purification and analytical planning for low-metal-background requirements. Analytical support : HPLC, NMR, MS, and ICP-MS can be discussed according to project needs. Scale-up support : process optimization and batch-size planning after technical review.

Overview

Butyne-DOTA (also known as 2-[4-[2-(but-3-ynylamino)-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid) (CAS 2125661-62-1, MF C20H33N5O7, MW 455.51) is part of the DOTA chelator family used in targeted radioligand and imaging-conjugate research. Practical chemistry topics include mono-functionalisation of the macrocycle, protection-group strategy, and conjugation chemistry with peptides or antibodies. Custom synthesis, process scale-up and supply planning are available through CHEMOS R&D and manufacturing facilities.

Applications

  • Butyne-DOTA (2125661-62-1) supply and analog preparation for research programs
  • Targeted radioligand therapy (TRT) building block — ⁹⁰Y / ¹⁷⁷Lu / ²²⁵Ac conjugates
  • DOTA-conjugate analog synthesis (e.g., DOTATATE-family research)
  • Process-development support for scalable chelator preparation

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