DOTAM-mono-acid
Chemical Name
2-[4,7,10-tris(2-amino-2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
DOTAM-mono-acid•DOTA
Structure: 
Product No
CH54010
CAS
913528-04-8
MF
C16H31N7O5
MW
401.46
Specification
| Catalog No. | CH54010 |
| CAS No. | 913528-04-8 |
| Molecular Formula | C16H31N7O5 |
| Molecular Weight | 401.46 |
CHEMOS Support for This Category
CHEMOS supports DOTA chelator and radiopharmaceutical building-block chemistry, including protected, activated, PEG-spaced, and conjugation-ready intermediates. DOTA and DOTA-GA derivatives : protected chelators, activated esters, maleimide derivatives, and linker-spaced variants. Custom chelator-linker synthesis : route design for chelator-linker-targeting moiety intermediates. Metal-sensitive process control : purification and analytical planning for low-metal-background requirements. Analytical support : HPLC, NMR, MS, and ICP-MS can be discussed according to project needs. Scale-up support : process optimization and batch-size planning after technical review.
Overview
DOTAM-mono-acid (also known as 2-[4,7,10-tris(2-amino-2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid) (CAS 913528-04-8, MF C16H31N7O5, MW 401.46) belongs to the DOTA-family chelator class for targeted radiopharmaceutical research. Programs typically examine residual metal control, kinetic inertness of the metal complex, and the available coupling handle. Project scale-up and custom synthesis are coordinated by the CHEMOS R&D team across laboratory and production sites.
Applications
- DOTAM-mono-acid (CAS 913528-04-8) route review and custom analog preparation
- Process-development support for scalable chelator preparation
- Targeted radioligand therapy (TRT) building block — ⁹⁰Y / ¹⁷⁷Lu / ²²⁵Ac conjugates
- DOTA-conjugate analog synthesis (e.g., DOTATATE-family research)
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