CHEMOS
Butyne-DOTA-tris(t-butyl ester)

Butyne-DOTA-tris(t-butyl ester)

Chemical Name

tert-butyl 2-[4-[2-(but-3-ynylamino)-2-oxoethyl]-7,10-bis[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetate

Butyne-DOTA-tris(t-butyl ester)•DOTA
Structure: Butyne-DOTA-tris(t-butyl ester) structure, CAS 2125661-54-1, MW 623.82
Product No
CH54011
CAS
2125661-54-1
MF
C32H57N5O7
MW
623.82
Specification
Catalog No.CH54011
CAS No.2125661-54-1
Molecular FormulaC32H57N5O7
Molecular Weight623.82

CHEMOS Support for This Category

CHEMOS supports DOTA chelator and radiopharmaceutical building-block chemistry, including protected, activated, PEG-spaced, and conjugation-ready intermediates. DOTA and DOTA-GA derivatives : protected chelators, activated esters, maleimide derivatives, and linker-spaced variants. Custom chelator-linker synthesis : route design for chelator-linker-targeting moiety intermediates. Metal-sensitive process control : purification and analytical planning for low-metal-background requirements. Analytical support : HPLC, NMR, MS, and ICP-MS can be discussed according to project needs. Scale-up support : process optimization and batch-size planning after technical review.

Overview

Butyne-DOTA-tris(t-butyl ester) (also known as tert-butyl 2-[4-[2-(but-3-ynylamino)-2-oxoethyl]-7,10-bis[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetate) (CAS 2125661-54-1, MF C32H57N5O7, MW 623.82) is a DOTA-family macrocyclic chelator building block used in radiopharmaceutical and metal-conjugate research. Programs working with this compound typically focus on selective functionalisation, radiometal compatibility (e.g., ⁹⁰Y, ¹⁷⁷Lu, ⁶⁴Cu), and conjugate stability. Custom synthesis, process scale-up and supply planning are available through CHEMOS R&D and manufacturing facilities.

Applications

  • Butyne-DOTA-tris(t-butyl ester) (CAS 2125661-54-1) route review and custom analog preparation
  • Process-development support for scalable chelator preparation
  • Targeted radioligand therapy (TRT) building block — ⁹⁰Y / ¹⁷⁷Lu / ²²⁵Ac conjugates
  • DOTA-conjugate analog synthesis (e.g., DOTATATE-family research)

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