CHEMOS
BCN-DOTA

BCN-DOTA

Chemical Name

2-[4-[2-[2-[[(1S,8R)-9-bicyclo[6.1.0]non-4-ynyl]methoxycarbonylamino]ethylamino]-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid

BCN-DOTA•DOTA
Structure: BCN-DOTA structure, CAS 2565792-45-0, MW 622.71
Product No
CH54014
CAS
2565792-45-0
MF
C29H46N6O9
MW
622.71
Specification
Catalog No.CH54014
CAS No.2565792-45-0
Molecular FormulaC29H46N6O9
Molecular Weight622.71

CHEMOS Support for This Category

CHEMOS supports DOTA chelator and radiopharmaceutical building-block chemistry, including protected, activated, PEG-spaced, and conjugation-ready intermediates. DOTA and DOTA-GA derivatives : protected chelators, activated esters, maleimide derivatives, and linker-spaced variants. Custom chelator-linker synthesis : route design for chelator-linker-targeting moiety intermediates. Metal-sensitive process control : purification and analytical planning for low-metal-background requirements. Analytical support : HPLC, NMR, MS, and ICP-MS can be discussed according to project needs. Scale-up support : process optimization and batch-size planning after technical review.

Overview

BCN-DOTA (also known as 2-[4-[2-[2-[[(1S,8R)-9-bicyclo[6.1.0]non-4-ynyl]methoxycarbonylamino]ethylamino]-2-oxoethyl]-7,10-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid) (CAS 2565792-45-0, MF C29H46N6O9, MW 622.71) is part of the DOTA chelator family used in targeted radioligand and imaging-conjugate research. Practical chemistry topics include mono-functionalisation of the macrocycle, protection-group strategy, and conjugation chemistry with peptides or antibodies. CHEMOS process-development team and large production base can support route refinement, scale-up and custom synthesis on request.

Applications

  • BCN-DOTA (CAS 2565792-45-0) route review and custom analog preparation
  • Targeted radioligand therapy (TRT) building block — ⁹⁰Y / ¹⁷⁷Lu / ²²⁵Ac conjugates
  • DOTA-conjugate analog synthesis (e.g., DOTATATE-family research)
  • Process-development support for scalable chelator preparation

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