CHEMOS
Propargyl-DOTA-tris(tBu)ester

Propargyl-DOTA-tris(tBu)ester

Chemical Name

tert-butyl 2-[4,7-bis[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-10-[2-oxo-2-(prop-2-ynylamino)ethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetate

Propargyl-DOTA-tris(tBu)ester•DOTA
Structure: Propargyl-DOTA-tris(tBu)ester structure, CAS 911197-00-7, MW 609.8
Product No
CH54016
CAS
911197-00-7
MF
C31H55N5O7
MW
609.8
Specification
Catalog No.CH54016
CAS No.911197-00-7
Molecular FormulaC31H55N5O7
Molecular Weight609.8

CHEMOS Support for This Category

CHEMOS supports DOTA chelator and radiopharmaceutical building-block chemistry, including protected, activated, PEG-spaced, and conjugation-ready intermediates. DOTA and DOTA-GA derivatives : protected chelators, activated esters, maleimide derivatives, and linker-spaced variants. Custom chelator-linker synthesis : route design for chelator-linker-targeting moiety intermediates. Metal-sensitive process control : purification and analytical planning for low-metal-background requirements. Analytical support : HPLC, NMR, MS, and ICP-MS can be discussed according to project needs. Scale-up support : process optimization and batch-size planning after technical review.

Overview

Propargyl-DOTA-tris(tBu)ester (also known as tert-butyl 2-[4,7-bis[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-10-[2-oxo-2-(prop-2-ynylamino)ethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetate) (CAS 911197-00-7, MF C31H55N5O7, MW 609.8) is part of the DOTA chelator family used in targeted radioligand and imaging-conjugate research. Practical chemistry topics include mono-functionalisation of the macrocycle, protection-group strategy, and conjugation chemistry with peptides or antibodies. CHEMOS process-development team and large production base can support route refinement, scale-up and custom synthesis on request.

Applications

  • Propargyl-DOTA-tris(tBu)ester (911197-00-7) as a starting point for downstream chemistry programs
  • Custom synthesis of mono-functionalised DOTA derivatives
  • Process-development support for scalable chelator preparation
  • Trace-metal control studies for radiopharmaceutical conjugates

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