CHEMOS
DOTA-bis(tert-butyl)ester

DOTA-bis(tert-butyl)ester

Chemical Name

2-[7-(carboxymethyl)-4,10-bis[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid

DOTA-bis(tert-butyl)ester•DOTA
Structure: DOTA-bis(tert-butyl)ester structure, CAS 913542-71-9, MW 516.63
Product No
CH54017
CAS
913542-71-9
MF
C24H44N4O8
MW
516.63
Specification
Catalog No.CH54017
CAS No.913542-71-9
Molecular FormulaC24H44N4O8
Molecular Weight516.63

CHEMOS Support for This Category

CHEMOS supports DOTA chelator and radiopharmaceutical building-block chemistry, including protected, activated, PEG-spaced, and conjugation-ready intermediates. DOTA and DOTA-GA derivatives : protected chelators, activated esters, maleimide derivatives, and linker-spaced variants. Custom chelator-linker synthesis : route design for chelator-linker-targeting moiety intermediates. Metal-sensitive process control : purification and analytical planning for low-metal-background requirements. Analytical support : HPLC, NMR, MS, and ICP-MS can be discussed according to project needs. Scale-up support : process optimization and batch-size planning after technical review.

Overview

DOTA-bis(tert-butyl)ester (also known as 2-[7-(carboxymethyl)-4,10-bis[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid) (CAS 913542-71-9, MF C24H44N4O8, MW 516.63) is a DOTA-family macrocyclic chelator building block used in radiopharmaceutical and metal-conjugate research. Programs working with this compound typically focus on selective functionalisation, radiometal compatibility (e.g., ⁹⁰Y, ¹⁷⁷Lu, ⁶⁴Cu), and conjugate stability. Project scale-up and custom synthesis are coordinated by the CHEMOS R&D team across laboratory and production sites.

Applications

  • DOTA-bis(tert-butyl)ester (913542-71-9) supply and analog preparation for research programs
  • Antibody and peptide radiolabeling research
  • DOTA-conjugate analog synthesis (e.g., DOTATATE-family research)
  • Custom synthesis of mono-functionalised DOTA derivatives

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