CHEMOS
NOTA-NHS ester

NOTA-NHS ester

Chemical Name

2-[4-(carboxymethyl)-7-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethyl]-1,4,7-triazonan-1-yl]acetic acid

NOTA-NHS ester•NOTA
Structure: NOTA-NHS ester structure, CAS 1338231-09-6, MW 400.38
Product No
CH55001
CAS
1338231-09-6
MF
C16H24N4O8
MW
400.38
Specification
Catalog No.CH55001
CAS No.1338231-09-6
Molecular FormulaC16H24N4O8
Molecular Weight400.38

CHEMOS Support for This Category

CHEMOS supports NOTA, NODAGA, and related chelator building-block projects for research and development use. NOTA-family derivatives : protected, activated, and pre-conjugated variants for downstream chemistry. Custom conjugate intermediates : chelator-linker and chelator-linker-peptide building blocks. Trace-metal awareness : process and analytical planning for radiolabeling-sensitive intermediates. Moisture-sensitive handling : packaging and handling requirements can be reviewed by compound form. Technical documentation : batch-specific COA and supporting technical information are provided according to confirmed specification.

Overview

NOTA-NHS ester (also known as 2-[4-(carboxymethyl)-7-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethyl]-1,4,7-triazonan-1-yl]acetic acid) (CAS 1338231-09-6, MF C16H24N4O8, MW 400.38) is part of the NOTA / NODAGA chelator class used in PET tracer development. Programs working with this compound typically focus on selective ring functionalisation, residual metal control, and conjugate compatibility with biomolecules. Bench-scale to larger-scale production is supported through CHEMOS organic chemistry workflows and dedicated process-development resources.

Applications

  • NOTA-NHS ester (1338231-09-6) as a starting point for downstream chemistry programs
  • PET tracer chemistry — ⁶⁸Ga and ⁶⁴Cu radiopharmaceutical building block
  • Peptide-NOTA / NODAGA conjugate synthesis (somatostatin, PSMA, FAPI etc.)
  • Process-development support for scalable chelator preparation

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