NOTA
Chemical Name
2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid
NOTA•NOTA
Structure: 
Product No
CH55003
CAS
56491-86-2
MF
C12H21N3O6
MW
303.31
Specification
| Catalog No. | CH55003 |
| CAS No. | 56491-86-2 |
| Molecular Formula | C12H21N3O6 |
| Molecular Weight | 303.31 |
CHEMOS Support for This Category
CHEMOS supports NOTA, NODAGA, and related chelator building-block projects for research and development use. NOTA-family derivatives : protected, activated, and pre-conjugated variants for downstream chemistry. Custom conjugate intermediates : chelator-linker and chelator-linker-peptide building blocks. Trace-metal awareness : process and analytical planning for radiolabeling-sensitive intermediates. Moisture-sensitive handling : packaging and handling requirements can be reviewed by compound form. Technical documentation : batch-specific COA and supporting technical information are provided according to confirmed specification.
Overview
NOTA (also known as 2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid) (CAS 56491-86-2, MF C12H21N3O6, MW 303.31) belongs to the NOTA / NODAGA macrocyclic chelator family used in radiopharmaceutical research. Typical chemistry questions involve protection-group strategy, mono-functionalisation, and conjugation chemistry for peptide or antibody coupling. Project scale-up and custom synthesis are coordinated by the CHEMOS R&D team across laboratory and production sites.
Applications
- NOTA (56491-86-2) as a starting point for downstream chemistry programs
- Peptide-NOTA / NODAGA conjugate synthesis (somatostatin, PSMA, FAPI etc.)
- Custom synthesis of mono-functionalised NOTA / NODAGA derivatives
- Process-development support for scalable chelator preparation
Need Custom Synthesis?
Our CDMO team provides end-to-end custom synthesis support from discovery through process development and scale-up.
Explore CDMO Services