CHEMOS
NOTA-FAPI

NOTA-FAPI

Chemical Name

2-[4-(carboxymethyl)-7-[2-[4-[3-[4-[[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]carbamoyl]quinolin-6-yl]oxypropyl]piperazin-1-yl]-2-oxoethyl]-1,4,7-triazonan-1-yl]acetic acid

NOTA-FAPI•NOTA
Structure: NOTA-FAPI structure, CAS 2374782-03-1, MW 771.82
Product No
CH55006
CAS
2374782-03-1
MF
C36H47F2N9O8
MW
771.82
Specification
Catalog No.CH55006
CAS No.2374782-03-1
Molecular FormulaC36H47F2N9O8
Molecular Weight771.82

CHEMOS Support for This Category

CHEMOS supports NOTA, NODAGA, and related chelator building-block projects for research and development use. NOTA-family derivatives : protected, activated, and pre-conjugated variants for downstream chemistry. Custom conjugate intermediates : chelator-linker and chelator-linker-peptide building blocks. Trace-metal awareness : process and analytical planning for radiolabeling-sensitive intermediates. Moisture-sensitive handling : packaging and handling requirements can be reviewed by compound form. Technical documentation : batch-specific COA and supporting technical information are provided according to confirmed specification.

Overview

NOTA-FAPI (also known as 2-[4-(carboxymethyl)-7-[2-[4-[3-[4-[[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]carbamoyl]quinolin-6-yl]oxypropyl]piperazin-1-yl]-2-oxoethyl]-1,4,7-triazonan-1-yl]acetic acid) (CAS 2374782-03-1, MF C36H47F2N9O8, MW 771.82) is a NOTA / NODAGA-family macrocyclic chelator building block used in ⁶⁸Ga and ⁶⁴Cu PET tracer research. Practical chemistry topics include rapid radiometal complexation, conjugation handle chemistry, and analytical control of metal-binding stability. CHEMOS process chemistry, organic synthesis routes and project scale-up support are offered for downstream programs.

Applications

  • NOTA-FAPI (CAS 2374782-03-1) preparation, route refinement, and analytical-control planning
  • Process-development support for scalable chelator preparation
  • Trace-metal control studies for PET tracer chemistry
  • PET tracer chemistry — ⁶⁸Ga and ⁶⁴Cu radiopharmaceutical building block

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