CHEMOS
Propargyl-NOTA(tBu)2

Propargyl-NOTA(tBu)2

Chemical Name

tert-butyl 2-[4-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-7-[2-oxo-2-(prop-2-ynylamino)ethyl]-1,4,7-triazonan-1-yl]acetate

Propargyl-NOTA(tBu)2•NOTA
Structure: Propargyl-NOTA(tBu)2 structure, CAS 1924677-40-6, MW 452.59
Product No
CH55019
CAS
1924677-40-6
MF
C23H40N4O5
MW
452.59
Specification
Catalog No.CH55019
CAS No.1924677-40-6
Molecular FormulaC23H40N4O5
Molecular Weight452.59

CHEMOS Support for This Category

CHEMOS supports NOTA, NODAGA, and related chelator building-block projects for research and development use. NOTA-family derivatives : protected, activated, and pre-conjugated variants for downstream chemistry. Custom conjugate intermediates : chelator-linker and chelator-linker-peptide building blocks. Trace-metal awareness : process and analytical planning for radiolabeling-sensitive intermediates. Moisture-sensitive handling : packaging and handling requirements can be reviewed by compound form. Technical documentation : batch-specific COA and supporting technical information are provided according to confirmed specification.

Overview

Propargyl-NOTA(tBu)2 (also known as tert-butyl 2-[4-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-7-[2-oxo-2-(prop-2-ynylamino)ethyl]-1,4,7-triazonan-1-yl]acetate) (CAS 1924677-40-6, MF C23H40N4O5, MW 452.59) belongs to the NOTA / NODAGA macrocyclic chelator family used in radiopharmaceutical research. Typical chemistry questions involve protection-group strategy, mono-functionalisation, and conjugation chemistry for peptide or antibody coupling. CHEMOS process-development team and large production base can support route refinement, scale-up and custom synthesis on request.

Applications

  • Propargyl-NOTA(tBu)2 (1924677-40-6) as a starting point for downstream chemistry programs
  • Rapid radiometal complexation studies for short-half-life isotopes
  • Custom synthesis of mono-functionalised NOTA / NODAGA derivatives
  • Trace-metal control studies for PET tracer chemistry

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