Thymidine (2'-Deoxythymidine)
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemischer Name
- 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
- MF
- C10H14N2O5
- MW
- 242.23
- Reinheit
- 99.9% (HPLC)
Thymidine, also written 2'-deoxythymidine (dT), is the thymine DNA nucleoside formed from thymine and 2-deoxy-β-D-ribose. CH64004 is identified by CAS 50-89-5, molecular formula C10H14N2O5, molecular weight 242.23, and PubChem CID 5789.
The source label "2'-deoxythymine" should be read as thymidine / 2'-deoxythymidine, not as the free base thymine. Thymidine is used in thymidine-kinase phosphorylation research and is the parent nucleoside behind tritiated-thymidine DNA-synthesis assays.
Synonyme
Thymidine; 2'-deoxythymidine; dT; deoxythymidine; thymine 2'-deoxyriboside
Identität und Spezifikationen
| Catalog No. | CH64004 |
| CAS No. | 50-89-5 |
| Molecular Formula | C10H14N2O5 |
| Molecular Weight | 242.23 |
| PubChem CID | 5789 |
| InChIKey | IQFYYKKMVGJFEH-XLPZGREQSA-N |
| Purity | 99.9% (HPLC) |
Technische Merkmale
- Nucleobase
- Thymine (5-methyluracil)
- Sugar
- 2'-Deoxyribose
- Nucleoside class
- Pyrimidine 2'-deoxyribonucleoside
- Packaging
- Custom packaging on request
- Water content
- <=0.5% KF
- Physical form
- White to almost white crystalline powder
- Stability
- Released 2024-05-13; retest May 2029
Anwendungskontext
- Thymidine-kinase research: literature reports thymidine as a substrate of thymidine kinase in phosphorylation studies.
- DNA-synthesis assays: tritiated thymidine ([3H]thymidine) is a classic DNA-synthesis marker, with thymidine as the parent nucleoside.
- Thymine DNA nucleoside reference: CH64004 provides the dT identity for nucleoside and oligonucleotide chemistry comparisons.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 5789
PubChem · CID 5789
Häufig gestellte Fragen
Is CH64004 thymidine or the base thymine?
It is thymidine, the nucleoside (CAS 50-89-5) — thymine joined to 2-deoxyribose. The brochure label "2'-deoxythymine" is imprecise; the free base thymine is a separate compound.
Why is thymidine used in DNA-synthesis assays?
Tritiated thymidine ([3H]thymidine) is incorporated into newly synthesized DNA, making it a classic reference marker for DNA synthesis; thymidine is the parent nucleoside for these assays.
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