2'-Deoxyuridine
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemischer Name
- 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
- MF
- C9H12N2O5
- MW
- 228.20
- Reinheit
- >99.0% (HPLC)
2'-Deoxyuridine (dU) is the uracil DNA nucleoside formed from uracil and 2-deoxy-β-D-ribose. CH64005 is listed under CAS 951-78-0, molecular formula C9H12N2O5, molecular weight 228.20, and PubChem CID 13712.
This record is distinct from uridine, the corresponding RNA nucleoside. In research literature, 2'-deoxyuridine appears as a substrate in thymidylate synthase activity assays and as a reference nucleoside for uracil-in-DNA and base-excision-repair studies.
Synonyme
2'-Deoxyuridine; deoxyuridine; dUrd; dU; 2'-deoxyribouridine
Identität und Spezifikationen
| Catalog No. | CH64005 |
| CAS No. | 951-78-0 |
| Molecular Formula | C9H12N2O5 |
| Molecular Weight | 228.20 |
| PubChem CID | 13712 |
| InChIKey | MXHRCPNRJAMMIM-SHYZEUOFSA-N |
| Purity | >99.0% (HPLC) |
Lagerbedingungen
Room temperature; cool and dark place below 15 C; inert gas
Technische Merkmale
- Nucleobase
- Uracil
- Sugar
- 2'-Deoxyribose
- Nucleoside class
- Pyrimidine 2'-deoxyribonucleoside
- Packaging
- 1 g glass bottle with plastic insert; Custom packaging on request
- Physical form
- Solid; white to almost white powder to crystal
Anwendungskontext
- Thymidylate synthase assay research: [5-³H]-2'-deoxyuridine is reported as the substrate in in situ thymidylate synthase activity assays.
- Base-excision-repair studies: uracil arising from dU in DNA is removed by uracil-DNA glycosylase, placing deoxyuridine in uracil-in-DNA research contexts.
- dU nucleoside reference: CH64005 provides the dU identity for nucleoside and oligonucleotide chemistry comparisons.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 13712
PubChem · CID 13712
Häufig gestellte Fragen
Is CH64005 the DNA or RNA nucleoside?
It is 2'-deoxyuridine (dU), the deoxyribonucleoside of uracil. The RNA counterpart, uridine, is listed separately by CHEMOS.
Why is 2'-deoxyuridine used in DNA-repair research?
Uracil that ends up in DNA (via dU/dUMP) is recognized and removed by uracil-DNA glycosylase, so 2'-deoxyuridine is a reference nucleoside in base-excision-repair studies.
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