5-Methyluridine (Ribothymidine)
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- Chemischer Name
- 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
- MF
- C10H14N2O6
- MW
- 258.23
- Reinheit
- >98.0% (HPLC, titration)
5-Methyluridine, also known as ribothymidine (rT), is a modified pyrimidine RNA nucleoside with 5-methyluracil linked to β-D-ribose. CH64014 is identified by CAS 1463-10-1, molecular formula C10H14N2O6, molecular weight 258.23, and PubChem CID 445408. It is distinct from thymidine (CH64004), which contains 2-deoxyribose.
In tRNA literature, ribothymidine is the conserved modified nucleoside at position 54 of the TΨC loop. This supports its use as a reference residue in tRNA-modification and modified-RNA chemistry research.
Synonyme
5-Methyluridine; ribothymidine; rT; 5-methyluracil riboside; m5U
Identität und Spezifikationen
| Catalog No. | CH64014 |
| CAS No. | 1463-10-1 |
| Molecular Formula | C10H14N2O6 |
| Molecular Weight | 258.23 |
| PubChem CID | 445408 |
| InChIKey | DWRXFEITVBNRMK-JXOAFFINSA-N |
| Purity | >98.0% (HPLC, titration) |
Lagerbedingungen
Room temperature; cool and dark place below 15 C; inert gas
Technische Merkmale
- Nucleobase
- 5-Methyluracil
- Sugar
- D-Ribose
- Base modification
- 5-Methyl
- Nucleoside class
- Modified pyrimidine ribonucleoside
- Packaging
- 1 g glass bottle with plastic insert; Custom packaging on request
- Water content
- <=5.0%
- Physical form
- Solid; white to almost white powder to crystal
Anwendungskontext
- tRNA-modification reference: 5-methyluridine is ribothymidine (rT), the conserved modified nucleoside at position 54 of the tRNA TΨC loop.
- Modified RNA nucleoside reference: CH64014 provides the 5-methyluridine / ribothymidine identity for modified-RNA and nucleoside chemistry comparisons.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 445408
PubChem · CID 445408
Häufig gestellte Fragen
What is the difference between 5-methyluridine and thymidine?
5-Methyluridine (ribothymidine) is the RNA nucleoside — 5-methyluracil on ribose. Thymidine is the DNA nucleoside — the same base on 2-deoxyribose. They are cataloged separately.
Why is 5-methyluridine relevant to tRNA research?
As ribothymidine (rT), it is the conserved modified nucleoside at position 54 of the tRNA TΨC loop, so it is a reference residue in studies of tRNA modification.
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