2',3'-Dideoxycytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C9H13N3O3
- MW
- 211.22
- Reinheit
- >=98.0% (HPLC)
2',3'-Dideoxycytidine (ddC) is a pyrimidine 2',3'-dideoxynucleoside with cytosine attached to a sugar lacking both the 2'- and 3'-hydroxyl groups. CH64016 is identified by CAS 7481-89-2, molecular formula C9H13N3O3, molecular weight 211.22, and PubChem CID 24066.
After conversion to the corresponding triphosphate, the missing 3'-hydroxyl prevents further DNA-chain extension after polymerase incorporation. That property defines its chain-termination context in DNA-polymerase and dideoxy-sequencing research.
Synonyme
2',3'-Dideoxycytidine; ddC; zalcitabine (research reagent naming)
Identität und Spezifikationen
| Catalog No. | CH64016 |
| CAS No. | 7481-89-2 |
| Molecular Formula | C9H13N3O3 |
| Molecular Weight | 211.22 |
| PubChem CID | 24066 |
| InChIKey | WREGKURFCTUGRC-POYBYMJQSA-N |
| Purity | >=98.0% (HPLC) |
Lagerbedingungen
-20 C
Technische Merkmale
- Nucleobase
- Cytosine
- Sugar
- 2',3'-Dideoxyribose
- Nucleoside class
- Pyrimidine dideoxynucleoside
- Research role
- Chain-terminator nucleotide precursor
- Packaging
- 250 mg glass bottle with plastic insert; Custom packaging on request
- Physical form
- White to pale cream crystals or crystalline powder or powder
Anwendungskontext
- Chain-terminator precursor: the corresponding ddCTP is incorporated by DNA polymerase as a chain-terminating nucleotide in dideoxy-sequencing research.
- DNA-polymerase research: ddC provides the cytidine dideoxynucleoside identity for polymerase incorporation and chain-termination studies.
- Dideoxynucleoside reference: CH64016 provides the 2',3'-dideoxycytidine identity for nucleoside chemistry comparisons.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 24066
PubChem · CID 24066
Häufig gestellte Fragen
Why is 2',3'-dideoxycytidine a chain terminator?
It lacks a 3'-hydroxyl, so once its triphosphate is incorporated by DNA polymerase no further nucleotide can be added and the chain terminates — the principle behind dideoxy sequencing.
How is ddC different from 2'-deoxycytidine?
2'-Deoxycytidine lacks only the 2'-hydroxyl and can extend a chain; 2',3'-dideoxycytidine lacks both 2'- and 3'-hydroxyls and acts as a chain terminator. 2'-deoxycytidine is cataloged separately.
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