2',3'-Dideoxyguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C10H13N5O3
- MW
- 251.24
- Reinheit
- >95.0% (HPLC, titration)
2',3'-Dideoxyguanosine (ddG) is a purine 2',3'-dideoxynucleoside with guanine attached to a sugar lacking both the 2'- and 3'-hydroxyl groups. CH64017 is identified by CAS 85326-06-3, molecular formula C10H13N5O3, molecular weight 251.24, and PubChem CID 135463029.
After conversion to the corresponding triphosphate, the missing 3'-hydroxyl prevents further DNA-chain extension after polymerase incorporation. That property defines its chain-termination context in DNA-polymerase and dideoxy-sequencing research.
Synonyme
2',3'-Dideoxyguanosine; ddG
Identität und Spezifikationen
| Catalog No. | CH64017 |
| CAS No. | 85326-06-3 |
| Molecular Formula | C10H13N5O3 |
| Molecular Weight | 251.24 |
| PubChem CID | 135463029 |
| InChIKey | OCLZPNCLRLDXJC-NTSWFWBYSA-N |
| Purity | >95.0% (HPLC, titration) |
Lagerbedingungen
0-10 C
Technische Merkmale
- Nucleobase
- Guanine
- Sugar
- 2',3'-Dideoxyribose
- Nucleoside class
- Purine dideoxynucleoside
- Research role
- Chain-terminator nucleotide precursor
- Packaging
- 250 mg glass bottle with plastic insert; Custom packaging on request
- Water content
- <=2.0%
- Physical form
- Solid; white to light yellow powder to crystal
Anwendungskontext
- Chain-terminator precursor: the corresponding ddGTP is incorporated by DNA polymerase as a chain-terminating nucleotide in dideoxy-sequencing research.
- DNA-polymerase research: ddG provides the guanosine dideoxynucleoside identity for polymerase incorporation and chain-termination studies.
- Dideoxynucleoside reference: CH64017 provides the 2',3'-dideoxyguanosine identity for nucleoside chemistry comparisons.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 135463029
PubChem · CID 135463029
Häufig gestellte Fragen
Why is 2',3'-dideoxyguanosine a chain terminator?
It lacks a 3'-hydroxyl, so once its triphosphate is incorporated by DNA polymerase no further nucleotide can be added and the chain terminates — the principle behind dideoxy sequencing.
How is ddG different from 2'-deoxyguanosine?
2'-Deoxyguanosine lacks only the 2'-hydroxyl and can extend a chain; 2',3'-dideoxyguanosine lacks both 2'- and 3'-hydroxyls and acts as a chain terminator. 2'-deoxyguanosine is cataloged separately.
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