2'-O-Methyluridine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C10H14N2O6
- MW
- 258.23
- Reinheit
- >98.0% (HPLC, titration)
2'-O-Methyluridine (2'-OMe-U, Um) is uridine with a 2'-O-methyl group on the ribose. CH64023 is identified by CAS 2140-76-3, molecular formula C10H14N2O6, molecular weight 258.23, and PubChem CID 102212. It has the same molecular formula as 5-methyluridine but a different methyl position and structure.
The same 2'-O-methyl motif appears in natural RNA modifications and in synthetic oligonucleotide research. In the cited literature, 2'-O-methyl ribonucleosides are discussed for nuclease resistance and RNA affinity, while Um is treated as a natural RNA-modification reference.
Synonyme
2'-O-Methyluridine; 2'-OMe-U; Um
Identität und Spezifikationen
| Catalog No. | CH64023 |
| CAS No. | 2140-76-3 |
| Molecular Formula | C10H14N2O6 |
| Molecular Weight | 258.23 |
| PubChem CID | 102212 |
| InChIKey | SXUXMRMBWZCMEN-ZOQUXTDFSA-N |
| Purity | >98.0% (HPLC, titration) |
Lagerbedingungen
0-10 C
Technische Merkmale
- Nucleobase
- Uracil
- Sugar
- D-Ribose
- Sugar modification
- 2'-O-Methyl
- Nucleoside class
- Modified pyrimidine ribonucleoside
- Packaging
- 1 g glass bottle with plastic insert; 5 g listed size; Custom packaging on request
- Physical form
- Solid; white to almost white powder to crystal
- Stability
- >=4 years
Anwendungskontext
- Nuclease-resistant oligonucleotide research: 2'-O-methyl residues are used as references for nuclease-resistant antisense and siRNA oligonucleotide studies.
- RNA-modification reference: Um is a naturally occurring 2'-O-methyl RNA modification, making CH64023 relevant to RNA-modification research.
- 2'-OMe ribonucleoside reference: CH64023 provides the 2'-O-methyluridine identity for nucleoside chemistry comparisons.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 102212
PubChem · CID 102212
Häufig gestellte Fragen
How is 2'-O-methyluridine different from 5-methyluridine?
Both share the formula C10H14N2O6, but 2'-O-methyluridine (Um) carries the methyl on the 2'-oxygen of the ribose, while 5-methyluridine (ribothymidine) carries it on carbon 5 of the base. They are constitutional isomers and are listed separately.
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