2'-O-Methyl-5-Methyluridine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C11H16N2O6
- MW
- 272.25
- Reinheit
- 100%
2'-O-Methyl-5-methyluridine (2'-OMe-5-Me-U; 2'-O-methylribothymidine, Tm) carries two modifications: a 2'-O-methyl group on the ribose and a 5-methyl group on the uracil base. CH64024 is identified by CAS 55486-09-4, molecular formula C11H16N2O6, molecular weight 272.25, and PubChem CID 191372.
In the cited literature, 2'-O-methyl ribonucleosides are discussed for nuclease resistance and RNA affinity, and 2'-O-methylation is a natural RNA-modification motif. CH64024 provides the defined dual 2'-O-methyl / 5-methyl uridine structure for oligonucleotide and modified-nucleoside comparisons; this does not establish the dual-modified structure itself as a natural RNA residue.
Synonyme
2'-O-Methyl-5-methyluridine; 2'-OMe-5-Me-U; 2'-O-methylribothymidine; Tm
Identität und Spezifikationen
| Catalog No. | CH64024 |
| CAS No. | 55486-09-4 |
| Molecular Formula | C11H16N2O6 |
| Molecular Weight | 272.25 |
| PubChem CID | 191372 |
| InChIKey | YHRRPHCORALGKQ-FDDDBJFASA-N |
| Purity | 100% |
Lagerbedingungen
-20 C
Technische Merkmale
- Nucleobase
- 5-Methyluracil
- Sugar
- D-Ribose
- Sugar modification
- 2'-O-Methyl
- Nucleoside class
- Modified pyrimidine ribonucleoside
- Packaging
- 250 mg; 1 g; 5 g; 25 g; 100 g; Custom packaging on request
- Physical form
- Solid
- Stability
- >=4 years
Anwendungskontext
- 2'-O-methyl oligonucleotide research: CH64024 is relevant to nuclease-resistant antisense and siRNA oligonucleotide studies involving 2'-O-methyl residues.
- Combined modified-nucleoside reference: it pairs a 2'-O-methyl sugar modification with a 5-methyl pyrimidine base for structural and nucleoside-chemistry comparisons.
- Modified ribonucleoside reference: CH64024 provides the 2'-O-methyl-5-methyluridine identity for nucleoside chemistry research.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 191372
PubChem · CID 191372
Häufig gestellte Fragen
What two modifications does CH64024 carry?
It has a 2'-O-methyl group on the ribose and a 5-methyl group on the uracil base (i.e. 2'-O-methylribothymidine), combining a sugar and a base modification in one residue.
How is it different from 5-methyluridine and 2'-O-methyluridine?
5-Methyluridine has only the base 5-methyl; 2'-O-methyluridine has only the 2'-O-methyl; CH64024 has both. All three are cataloged separately.
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