2'-Fluoro-2'-deoxyadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C10H12FN5O3
- MW
- 269.23
- Reinheit
- 99.2% (HPLC)
2'-Fluoro-2'-deoxyadenosine (2'-F-dA) is an adenosine analog in which the 2'-hydroxyl of the sugar is replaced by fluorine. CH64025 is identified by CAS 64183-27-3, molecular formula C10H12FN5O3, molecular weight 269.23, and PubChem CID 100253.
The cited oligonucleotide literature discusses 2'-fluoro modifications in siRNA and antisense research for nuclease resistance and binding affinity. CH64025 provides the adenine 2'-fluoro-2'-deoxy nucleoside identity for related oligonucleotide-modification studies.
Synonyme
2'-Fluoro-2'-deoxyadenosine; 2'-F-dA; 2'-F-A
Identität und Spezifikationen
| Catalog No. | CH64025 |
| CAS No. | 64183-27-3 |
| Molecular Formula | C10H12FN5O3 |
| Molecular Weight | 269.23 |
| PubChem CID | 100253 |
| InChIKey | ZGYYPTJWJBEXBC-QYYRPYCUSA-N |
| Purity | 99.2% (HPLC) |
Lagerbedingungen
-20 C
Technische Merkmale
- Nucleobase
- Adenine
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Nucleoside class
- 2'-Fluoro purine nucleoside
- Packaging
- Custom packaging on request
- Water content
- 0.08% w/w by KF
- Physical form
- White, fluffy powder
- Stability
- >=4 years
Anwendungskontext
- 2'-F oligonucleotide research: CH64025 is relevant to siRNA and antisense modification studies involving 2'-fluoro adenine residues.
- Modified-nucleic-acid studies: the 2'-fluoro motif is discussed in duplex-affinity and nuclease-resistance research on modified oligonucleotides.
- 2'-F nucleoside reference: CH64025 provides the 2'-fluoro-2'-deoxyadenosine identity for nucleoside chemistry research.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 100253
PubChem · CID 100253
Häufig gestellte Fragen
How is 2'-F-dA different from 2'-deoxyadenosine?
2'-Deoxyadenosine has a hydrogen at the 2' position; 2'-fluoro-2'-deoxyadenosine has a fluorine there. 2'-deoxyadenosine is cataloged separately.
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