2'-Fluoro-2'-deoxycytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C9H12FN3O4
- MW
- 245.21
- Reinheit
- >98.0% (titration)
2'-Fluoro-2'-deoxycytidine (2'-F-dC) is a cytidine analog in which the 2'-hydroxyl of the sugar is replaced by fluorine. CH64026 is identified by CAS 10212-20-1, molecular formula C9H12FN3O4, molecular weight 245.21, and PubChem CID 101507.
The cited oligonucleotide literature discusses 2'-fluoro modifications in siRNA and antisense research for nuclease resistance and binding affinity. CH64026 provides the cytidine 2'-fluoro-2'-deoxy nucleoside identity for related oligonucleotide-modification studies.
Synonyme
2'-Fluoro-2'-deoxycytidine; 2'-F-dC; 2'-F-C
Identität und Spezifikationen
| Catalog No. | CH64026 |
| CAS No. | 10212-20-1 |
| Molecular Formula | C9H12FN3O4 |
| Molecular Weight | 245.21 |
| PubChem CID | 101507 |
| InChIKey | NVZFZMCNALTPBY-XVFCMESISA-N |
| Purity | >98.0% (titration) |
Lagerbedingungen
Room temperature; cool and dark below 15 C
Technische Merkmale
- Nucleobase
- Cytosine
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Nucleoside class
- 2'-Fluoro pyrimidine nucleoside
- Packaging
- 1 g glass bottle with plastic insert; Custom packaging on request
- Water content
- <=10.0%
- Physical form
- Solid; white to almost white powder to crystal
Anwendungskontext
- 2'-F oligonucleotide research: CH64026 is relevant to siRNA and antisense modification studies involving 2'-fluoro cytidine residues.
- Modified-nucleic-acid studies: the 2'-fluoro motif is discussed in duplex-affinity and nuclease-resistance research on modified oligonucleotides.
- 2'-F nucleoside reference: CH64026 provides the 2'-fluoro-2'-deoxycytidine identity for nucleoside chemistry research.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 101507
PubChem · CID 101507
Häufig gestellte Fragen
How is 2'-F-dC different from 2'-deoxycytidine?
2'-Deoxycytidine has a hydrogen at the 2' position; 2'-fluoro-2'-deoxycytidine has a fluorine there. 2'-deoxycytidine is cataloged separately.
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