2'-Fluoro-2'-deoxyuridine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C9H11FN2O5
- MW
- 246.19
- Reinheit
- >=99.0% (HPLC)
2'-Fluoro-2'-deoxyuridine (2'-F-dU) is a uridine analog in which the 2'-hydroxyl of the sugar is replaced by fluorine. CH64028 is identified by CAS 784-71-4, molecular formula C9H11FN2O5, molecular weight 246.19, and PubChem CID 150851. The fluorine is on the sugar, which distinguishes CH64028 from base-fluorinated 5-fluoro uridine derivatives.
The cited oligonucleotide literature discusses 2'-fluoro modifications in siRNA and antisense research for nuclease resistance and binding affinity. CH64028 provides the uridine 2'-fluoro-2'-deoxy nucleoside identity for related oligonucleotide-modification studies.
Synonyme
2'-Fluoro-2'-deoxyuridine; 2'-F-dU; 2'-F-U
Identität und Spezifikationen
| Catalog No. | CH64028 |
| CAS No. | 784-71-4 |
| Molecular Formula | C9H11FN2O5 |
| Molecular Weight | 246.19 |
| PubChem CID | 150851 |
| InChIKey | UIYWFOZZIZEEKJ-XVFCMESISA-N |
| Purity | >=99.0% (HPLC) |
Lagerbedingungen
4 C
Technische Merkmale
- Nucleobase
- Uracil
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Nucleoside class
- 2'-Fluoro pyrimidine nucleoside
- Packaging
- Custom packaging on request
- Water content
- <=3.0% KF
- Physical form
- White crystalline powder
- Stability
- >=4 years
Anwendungskontext
- 2'-F oligonucleotide research: CH64028 is relevant to siRNA and antisense modification studies involving 2'-fluoro uridine residues.
- Modified-nucleic-acid studies: the 2'-fluoro motif is discussed in duplex-affinity and nuclease-resistance research on modified oligonucleotides.
- 2'-F nucleoside reference: CH64028 provides the 2'-fluoro-2'-deoxyuridine identity for nucleoside chemistry research.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 150851
PubChem · CID 150851
Häufig gestellte Fragen
Is this 2'-fluoro or 5-fluoro uridine?
It is 2'-fluoro-2'-deoxyuridine — the fluorine is on the 2' position of the sugar. It is different from 5-fluoro uridine derivatives, where the fluorine is on the uracil base.
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