2'-O-(2-Methoxyethyl)guanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C13H19N5O6
- MW
- 341.32
- Reinheit
- >=98%
2'-O-(2-Methoxyethyl)guanosine (2'-O-MOE-G) is guanosine with a 2'-O-(2-methoxyethyl) group on the ribose. CH64031 is identified by CAS 473278-54-5, molecular formula C13H19N5O6, molecular weight 341.32, and PubChem CID 135544588.
In the cited structure and stability literature, 2'-O-MOE ribonucleosides are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides. CH64031 provides the guanosine 2'-O-MOE nucleoside identity for related antisense-oligonucleotide research.
Synonyme
2'-O-(2-Methoxyethyl)guanosine; 2'-O-MOE-G; 2'-MOE-G
Identität und Spezifikationen
| Catalog No. | CH64031 |
| CAS No. | 473278-54-5 |
| Molecular Formula | C13H19N5O6 |
| Molecular Weight | 341.32 |
| PubChem CID | 135544588 |
| InChIKey | DLLBJSLIKOKFHE-WOUKDFQISA-N |
| Purity | >=98% |
Lagerbedingungen
-20 C
Technische Merkmale
- Nucleobase
- Guanine
- Sugar
- D-Ribose
- Sugar modification
- 2'-O-(2-Methoxyethyl) (MOE)
- Nucleoside class
- MOE-modified purine ribonucleoside
- Packaging
- Custom packaging on request
- Physical form
- Solid
- Stability
- >=4 years
Anwendungskontext
- MOE gapmer antisense research: CH64031 is relevant to gapmer antisense studies involving 2'-O-MOE guanine residues.
- Modified-nucleic-acid studies: cited literature discusses 2'-O-MOE residues in RNA-affinity and nuclease-resistance studies of modified oligonucleotides.
- 2'-O-MOE nucleoside reference: CH64031 provides the 2'-O-(2-methoxyethyl)guanosine identity for nucleoside chemistry research.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 135544588
PubChem · CID 135544588
Häufig gestellte Fragen
How is 2'-O-MOE-guanosine different from 2'-O-methylguanosine?
Both are 2'-O-alkyl modifications, but MOE is a larger 2-methoxyethyl group versus a single methyl in 2'-O-methyl. 2'-O-methylguanosine is cataloged separately.
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