2'-O-(2-Methoxyethyl)uridine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C12H18N2O7
- MW
- 302.28
- Reinheit
- >=98%
2'-O-(2-Methoxyethyl)uridine (2'-O-MOE-U) is uridine with a 2'-O-(2-methoxyethyl) group on the ribose. CH64034 is identified by CAS 223777-15-9, molecular formula C12H18N2O7, molecular weight 302.28, and PubChem CID 10881175.
In the cited structure and stability literature, 2'-O-MOE ribonucleosides are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides. CH64034 provides the uridine 2'-O-MOE nucleoside identity for related antisense-oligonucleotide research.
Synonyme
2'-O-(2-Methoxyethyl)uridine; 2'-O-MOE-U; 2'-MOE-U
Identität und Spezifikationen
| Catalog No. | CH64034 |
| CAS No. | 223777-15-9 |
| Molecular Formula | C12H18N2O7 |
| Molecular Weight | 302.28 |
| PubChem CID | 10881175 |
| InChIKey | XTXNROBDOKPICP-QCNRFFRDSA-N |
| Purity | >=98% |
Lagerbedingungen
0-10 C
Technische Merkmale
- Nucleobase
- Uracil
- Sugar
- D-Ribose
- Sugar modification
- 2'-O-(2-Methoxyethyl) (MOE)
- Nucleoside class
- MOE-modified pyrimidine ribonucleoside
- Packaging
- 1 g; Custom packaging on request
- Physical form
- Solid; white to light yellow powder to crystal
Anwendungskontext
- MOE gapmer antisense research: CH64034 is relevant to gapmer antisense studies involving 2'-O-MOE uridine residues.
- Modified-nucleic-acid studies: cited literature discusses 2'-O-MOE residues in RNA-affinity and nuclease-resistance studies of modified oligonucleotides.
- 2'-O-MOE nucleoside reference: CH64034 provides the 2'-O-(2-methoxyethyl)uridine identity for nucleoside chemistry research.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 10881175
PubChem · CID 10881175
Häufig gestellte Fragen
How is 2'-O-MOE-uridine different from 2'-O-methyluridine?
Both are 2'-O-alkyl modifications, but MOE is a larger 2-methoxyethyl group versus a single methyl in 2'-O-methyl. 2'-O-methyluridine is cataloged separately.
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