7-Deaza-2'-deoxyadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C11H14N4O3
- MW
- 250.25
- Reinheit
- >98%
7-Deaza-2'-deoxyadenosine, also called 2'-deoxytubercidin (c7dA), is 2'-deoxyadenosine in which the purine N7 nitrogen is replaced by carbon, giving a pyrrolo[2,3-d]pyrimidine base. CH64045 is identified by CAS 60129-59-1, molecular formula C11H14N4O3, molecular weight 250.25, and PubChem CID 3006222.
The cited oligonucleotide literature discusses 7-deaza-dA analogs in base-pairing, metal-mediated base-pair, and duplex-stability studies where the N7 position is being examined. CH64045 provides the 7-deaza-2'-deoxyadenosine identity for related base-analog research.
Synonyme
7-Deaza-2'-deoxyadenosine; 2'-deoxytubercidin; c7dA; 7-deaza-dA
Identität und Spezifikationen
| Catalog No. | CH64045 |
| CAS No. | 60129-59-1 |
| Molecular Formula | C11H14N4O3 |
| Molecular Weight | 250.25 |
| PubChem CID | 3006222 |
| InChIKey | NIJSNUNKSPLDTO-DJLDLDEBSA-N |
| Purity | >98% |
Lagerbedingungen
2-8 C; keep dark and dry
Technische Merkmale
- Nucleobase analog
- 7-Deazaadenine
- Sugar
- 2'-Deoxyribose
- Base modification
- 7-Deaza (N7 replaced by carbon)
- Research role
- Modified-oligonucleotide building-block reference
- Packaging
- 500 mg; 1 g; 10 g; 25 g; 50 g; 100 g; Custom packaging on request
- Physical form
- White to off-white powder
Anwendungskontext
- 7-Deazapurine oligonucleotide research: CH64045 is relevant to base-pairing, metal-mediated base-pair, and duplex-stability studies involving the N7→C base modification.
- N7-position interaction studies: the 7-deaza base helps compare DNA systems where Hoogsteen or metal-binding behavior at the purine N7 position is being evaluated.
- Base-analog reference: CH64045 provides the 7-deaza-2'-deoxyadenosine identity for nucleoside chemistry research.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 3006222
PubChem · CID 3006222
Häufig gestellte Fragen
What is different about 7-deaza-2'-deoxyadenosine?
The purine N7 nitrogen is replaced by carbon, forming a 7-deazapurine / pyrrolo[2,3-d]pyrimidine base. This removes the N7 site considered in Hoogsteen and metal-binding studies.
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