5-TFA-aha-2'-deoxyuridine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C20H27F3N4O7
- MW
- 492.4
- Reinheit
- >98.00%
5-TFA-aha-2'-deoxyuridine is 2'-deoxyuridine carrying a longer amino-linker (the "aha" arm) at the C5 position of uracil, with the linker's terminal amine protected as a trifluoroacetamide (TFA). CH64055 is identified by CAS 252337-58-9, molecular formula C20H27F3N4O7, molecular weight 492.4, PubChem CID 15484914, and InChIKey CSMRZKBUOFUSRQ-JHCHYBNPSA-N.
Compared with the shorter C5 aminopropynyl linker in 5-TFA-ap-2'-deoxyuridine, the larger formula and PubChem structure indicate a longer spacer arm. The cited labeling literature discusses amine-linker nucleosides as motifs for covalent fluorophore attachment in nucleoside and oligonucleotide labeling research.
Synonyme
5-TFA-aha-dU; 5-[TFA-protected aminohexanoyl-type amino-linker]-2'-deoxyuridine
Identität und Spezifikationen
| Catalog No. | CH64055 |
| CAS No. | 252337-58-9 |
| Molecular Formula | C20H27F3N4O7 |
| Molecular Weight | 492.4 |
| PubChem CID | 15484914 |
| InChIKey | CSMRZKBUOFUSRQ-JHCHYBNPSA-N |
| Purity | >98.00% |
Lagerbedingungen
2-8 C, away from moisture, sealed storage
Technische Merkmale
- Nucleobase
- Uracil
- Sugar
- 2'-Deoxyribose
- C5 linker
- Aminohexanoyl-type long spacer
- Amine protection
- Trifluoroacetyl (TFA)
- Packaging
- 25 mg; 100 mg; Custom packaging on request
Anwendungskontext
- Long-spacer labeling research: CH64055 combines a 2'-deoxyuridine identity with a C5 TFA-protected "aha" amino-linker for oligonucleotide labeling and linker-spacing studies.
- Amine-linker labeling studies: the TFA-protected terminal amine represents a protected amine-linker motif discussed for covalent fluorophore attachment after deprotection.
- Base-analog reference: CH64055 provides the 5-TFA-aha-2'-deoxyuridine identity for nucleoside chemistry research.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 15484914
PubChem · CID 15484914
Häufig gestellte Fragen
How is the 'aha' linker different from the 'ap' linker?
The 'aha' amino-linker is longer than the propynyl 'ap' linker, giving a larger spacer between the base and the terminal amine. The shorter 5-TFA-ap-2'-deoxyuridine is cataloged separately.
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