N6-Benzoyl-2'-deoxyadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C17H17N5O4
- MW
- 355.35
- Reinheit
- >=98.0% (HPLC)
N6-Benzoyl-2'-deoxyadenosine (dABz) is 2'-deoxyadenosine whose adenine exocyclic N6-amine is protected with a benzoyl group. CH64072 is identified by CAS 4546-72-9, molecular formula C17H17N5O4, molecular weight 355.35, PubChem CID 107558, and InChIKey PIXHJAPVPCVZSV-YNEHKIRRSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups on nucleobases and their removal during deprotection. CH64072 provides the N6-benzoyl-protected 2'-deoxyadenosine identity for DNA building-block and nucleoside chemistry research.
Synonyme
N6-Benzoyl-2'-deoxyadenosine; N6-Bz-dA; dABz
Identität und Spezifikationen
| Catalog No. | CH64072 |
| CAS No. | 4546-72-9 |
| Molecular Formula | C17H17N5O4 |
| Molecular Weight | 355.35 |
| PubChem CID | 107558 |
| InChIKey | PIXHJAPVPCVZSV-YNEHKIRRSA-N |
| Purity | >=98.0% (HPLC) |
Lagerbedingungen
-20 C
Technische Merkmale
- Nucleobase
- Adenine
- Sugar
- 2'-Deoxyribose
- Base protection
- N6-Benzoyl
- Synthesis role
- Base-protected DNA nucleoside intermediate
- Packaging
- Custom packaging on request
- Physical form
- crystalline solid
- Stability
- >=4 years
Anwendungskontext
- Base-protected DNA building block: the N6-benzoyl group masks the adenine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- Adenine (dA) monomer precursor context: CH64072 is the base-protected 2'-deoxyadenosine identity relevant to adenine building-block preparation.
- Nucleoside chemistry reference: CH64072 provides the N6-benzoyl-2'-deoxyadenosine (dABz) identity for nucleoside chemistry research.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 107558
PubChem · CID 107558
Häufig gestellte Fragen
Why is the N6-amine of this deoxyadenosine benzoylated?
In oligonucleotide synthesis the reactive exocyclic amine of adenine is masked with a protecting group such as benzoyl to prevent side reactions; the benzoyl group is later removed during deprotection.
How does it differ from 2'-deoxyadenosine?
It carries a benzoyl group on the adenine N6-amine, whereas 2'-deoxyadenosine is unprotected. 2'-deoxyadenosine is cataloged separately.
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