N4-Acetyl-2'-deoxycytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
Produktübersicht
Kurzüberblick
- Produktfamilie
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- MF
- C11H15N3O5
- MW
- 269.25
- Reinheit
- >=99.0% (HPLC)
N4-Acetyl-2'-deoxycytidine (dCAc) is 2'-deoxycytidine whose cytosine exocyclic N4-amine is protected with an acetyl group. CH64075 is identified by CAS 32909-05-0, molecular formula C11H15N3O5, molecular weight 269.25, PubChem CID 11346228, and InChIKey RWYFZABPLDFELM-QXFUBDJGSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups on nucleobases and their removal during deprotection. CH64075 provides the N4-acetyl-protected 2'-deoxycytidine identity for DNA building-block and nucleoside chemistry research.
Synonyme
N4-Acetyl-2'-deoxycytidine; N4-Ac-dC; dCAc
Identität und Spezifikationen
| Catalog No. | CH64075 |
| CAS No. | 32909-05-0 |
| Molecular Formula | C11H15N3O5 |
| Molecular Weight | 269.25 |
| PubChem CID | 11346228 |
| InChIKey | RWYFZABPLDFELM-QXFUBDJGSA-N |
| Purity | >=99.0% (HPLC) |
Lagerbedingungen
2-8 C; dark and dry
Technische Merkmale
- Nucleobase
- Cytosine
- Sugar
- 2'-Deoxyribose
- Base protection
- N4-Acetyl
- Synthesis role
- Base-protected DNA nucleoside intermediate
- Packaging
- 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 5 g; 10 g; 25 g; 100 g; 250 g; Custom packaging on request
- Physical form
- white off-white to faint-yellow powder
- Stability
- Powder: 3 years; in solution: 1 year
Anwendungskontext
- Base-protected DNA building block: the N4-acetyl group masks the cytosine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- Cytosine (dC) monomer precursor context: CH64075 is the acetyl-protected 2'-deoxycytidine identity relevant to cytosine building-block preparation.
- Nucleoside chemistry reference: CH64075 provides the N4-acetyl-2'-deoxycytidine (dCAc) identity for nucleoside chemistry research.
Zugehörige technische Ressourcen
Öffentliche Quellen
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem-Verbindung 11346228
PubChem · CID 11346228
Häufig gestellte Fragen
Why is the N4-amine of this deoxycytidine acetylated?
In oligonucleotide synthesis the reactive exocyclic amine of cytosine is masked with a protecting group such as acetyl to prevent side reactions; the acetyl group is later removed during deprotection.
How does it differ from N4-benzoyl-2'-deoxycytidine?
Both protect the cytosine N4-amine, but this one uses an acetyl group rather than benzoyl. N4-benzoyl-2'-deoxycytidine is cataloged separately.
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